Adrenal cryptococcosis in an immunosuppressed patient showing intensely increased metabolic activity on ¹⁸F-FDG PET/CT

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• 作者：Georgios Z. Papadakis ; Steven M. Holland ; Martha Quezado ; Nicholas J. Patronas
• 关键词：18F ; FDG PET/CT ; Adrenal cryptococcosis ; Primary adrenal insufficiency
• 刊名：Endocrine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：54
• 期：3
• 页码：834-836
• 全文大小：792 KB
• 刊物主题：Endocrinology; Diabetes; Internal Medicine; Science, general;
• 出版者：Springer US
• ISSN：1559-0100
• 卷排序：54

文摘

Disseminated cryptococcosis most commonly occurs in immunosuppressed patients and can rarely affect the adrenal glands. We report on a patient with biopsy proven bilateral adrenal cryptococcosis resulting in primary adrenal insufficiency, which was evaluated with whole-body positron emission tomography/computed tomography scan using 18F-FDG. Both enlarged adrenal glands presented intensely increased 18F-FDG activity in the periphery, while central necrotic regions were photopenic. Although diagnosis was established by adrenal gland biopsy, 18F-FDG positron emission tomography/computed tomography scan can significantly contribute to the assessment of disease activity and monitoring of treatment response. Furthermore, fungal infections should always be considered when encountering hypermetabolic adrenal masses, especially in the setting of immunodeficient patients.