Increased Risk for Substance Use-Related Problems in Autism Spectrum Disorders: A Population-Based Cohort Study

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• 作者：Agnieszka Butwicka ; Niklas Långström…
• 关键词：Autism spectrum disorder ; Addiction ; ADHD ; Intellectual disability ; ICD
• 刊名：Journal of Autism and Developmental Disorders
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：47
• 期：1
• 页码：80-89
• 全文大小：608KB
• 刊物类别：Behavioral Science
• 刊物主题：Child and School Psychology; Pediatrics; Neurosciences; Public Health;
• 出版者：Springer US
• ISSN：1573-3432
• 卷排序：47

文摘

Despite limited and ambiguous empirical data, substance use-related problems have been assumed to be rare among patients with autism spectrum disorders (ASD). Using Swedish population-based registers we identified 26,986 individuals diagnosed with ASD during 1973–2009, and their 96,557 non-ASD relatives. ASD, without diagnosed comorbidity of attention deficit hyperactivity disorder (ADHD) or intellectual disability, was related to a doubled risk of substance use-related problems. The risk of substance use-related problems was the highest among individuals with ASD and ADHD. Further, risks of substance use-related problems were increased among full siblings of ASD probands, half-siblings and parents. We conclude that ASD is a risk factor for substance use-related problems. The elevated risks among relatives of probands with ASD suggest shared familial (genetic and/or shared environmental) liability.