Contrasting the Influence of Cationic Amino Acids on the Viscosity and Stability of a Highly Concentrated Monoclonal Antibody
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- 作者：Barton J. Dear ; Jessica J. Hung ; Thomas M. Truskett…
- 关键词：KEY WORDSantibody ; arginine ; histidine ; rheology ; viscosity
- 刊名：Pharmaceutical Research
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：34
- 期：1
- 页码：193-207
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering;
- 出版者：Springer US
- ISSN：1573-904X
- 卷排序：34
文摘
PurposeTo explain the effects of cationic amino acids and other co-solutes on the viscosity, stability and protein-protein interactions (PPI) of highly concentrated (≥200 mg/ml) monoclonal antibody (mAb) solutions to advance subcutaneous injection.