Tumor Immunology Viewed from Alternative Animal Models—the Xenopus Story

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• 作者：Maureen Banach ; Jacques Robert
• 关键词：Vertebrates ; Amphibians ; Tumor immunity ; MHC class I ; like ; Innate T cells
• 刊名：Current Pathobiology Reports
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：5
• 期：1
• 页码：49-56
• 全文大小：
• 刊物主题：Pathology;
• 出版者：Springer US
• ISSN：2167-485X
• 卷排序：5

文摘

Purpose of ReviewNonmammalian comparative animal models are important not only to gain fundamental evolutionary understanding of the complex interactions of tumors with the immune system but also to better predict the applicability of novel immunotherapeutic approaches to humans. After reviewing recent advances in developing alternative models, we focus on the amphibian Xenopus laevis and its usefulness in deciphering the perplexing roles of MHC class I-like molecules and innate (i)T cells in tumor immunity.