Interactions of human microglia cells with Japanese encephalitis virus
详细信息 查看全文
- 作者：Nils Lannes ; Viviane Neuhaus ; Brigitte Scolari ; Solange Kharoubi-Hess…
- 关键词：Human microglia ; Japanese encephalitis virus ; Inflammation ; Chemokine ligand ; receptor ; Viral transmission
- 刊名：Virology Journal
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：14
- 期：1
- 全文大小：1532KB
- 刊物主题：Virology;
- 出版者：BioMed Central
- ISSN：1743-422X
- 卷排序：14
文摘
BackgroundJapanese encephalitis virus (JEV) is a neurotropic flavivirus causing mortality and morbidity in humans. Severe Japanese encephalitis cases display strong inflammatory responses in the central nervous system and an accumulation of viral particles in specific brain regions. Microglia cells are the unique brain-resident immune cell population with potent migratory functions and have been proposed to act as a viral reservoir for JEV. Animal models suggest that the targeting of microglia by JEV is partially responsible for inflammatory reactions in the brain. Nevertheless, the interactions between human microglia and JEV are poorly documented.