The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas

详细信息    查看全文

• 作者：Yoshihiro Mezawa ; Akira Orimo
• 关键词：Carcinoma ; associated fibroblasts (CAFs) ; Myofibroblasts ; Tumor ; associated stroma ; Tumor ; suppressive stromal fibroblasts ; CAF heterogeneity
• 刊名：Cell and Tissue Research
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：365
• 期：3
• 页码：675-689
• 全文大小：2,475 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Human Genetics
  Proteomics
  Molecular Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0878
• 卷排序：365

文摘

Carcinoma-associated fibroblasts (CAFs) constitute a substantial proportion of the non-neoplastic mesenchymal cell compartment in various human tumors. These fibroblasts are phenotypically converted from their progenitors via interactions with nearby cancer cells during the course of tumor progression. The resulting CAFs, in turn, support the growth and progression of carcinoma cells. These fibroblasts have a major influence on the hallmarks of carcinoma and promote tumor malignancy through the secretion of tumor-promoting growth factors, cytokines and exosomes, as well as through the remodeling of the extracellular matrix. Coevolution of CAFs and carcinoma cells during tumorigenesis is therefore essential for progression into fully malignant tumors. Recent studies have revealed the molecular mechanisms underlying CAF functions, especially in tumor invasion, metastasis and drug resistance and have highlighted the significant heterogeneity among these cells. In this review, we summarize the impacts of recently identified roles of tumor-promoting CAFs and discuss the therapeutic implications of targeting the heterotypic interactions of these fibroblasts with carcinoma cells.