Effect of interactions between genetic polymorphisms and cigarette smoking on plasma triglyceride levels in elderly Koreans: the Hallym Aging Study

详细信息    查看全文

• 作者：Eun Pyo Hong ; Ji Wan Park ; Jun-Gyo Suh ; Dong-Hyun Kim
• 关键词：Aging cohort ; Cigarette smoking ; Gene ; environment interaction ; Single nucleotide polymorphism ; Triglycerides
• 刊名：Genes & Genomics
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：37
• 期：2
• 页码：173-181
• 全文大小：260 KB
• 参考文献：1. Ariza MJ, Sánchez-Chaparro MA, Barón FJ, Hornos AM, Calvo-Bonacho E, Rioja J, Valdivielso P, Gelpi JA, González-Santos P (2010) Additive effects of LPL, APOA5 and APOE variant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study. BMC Med Genet 11:66 CrossRef
  2. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-65 CrossRef
  3. Cauchi S, Nead KT, Choquet H, Horber F, Potoczna N, Balkau B, Marre M, Charpentier G, Froguel P, Meyre D (2008) The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies. BMC Med Genet 9:45 CrossRef
  4. Cho YG, Song HJ, Lee SK, Jang SN, Jeong JY, Choi YH, Hong KS, Choi MG, Kang SH, Kang JH et al (2009) The relationship between body fat mass and erectile dysfunction in Korean men: Hallym Aging Study. Int J Impot Res 21:179-86 CrossRef
  5. Connelly JJ, Wang T, Cox JE, Haynes C, Wang L, Shah SH, Crosslin DR, Hale AB, Nelson S, Crossman DC et al (2006) GATA2 is associated with familial early-onset coronary artery disease. PLoS Genet 2:e139 CrossRef
  6. Grundy SM, Benjamin IJ, Burke GL, Chait A, Eckel RH, Howard BV, Mitch W, Smith SC Jr, Sowers JR (1999) Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation 100:1134-146 CrossRef
  7. Heller DA, de Faire U, Pedersen NL, Dahlén G, McClearn GE (1993) Genetic and environmental influences on serum lipid levels in twins. N Engl J Med 328:1150-156 CrossRef
  8. Hokanson JE, Austin MA (1996) Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. J Cardiovasc Risk 3:213-19 CrossRef
  9. Hsu AP, Sampaio EP, Khan J, Calvo KR, Lemieux JE, Patel SY, Frucht DM, Vinh DC, Auth RD, Freeman AF et al (2011) Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome. Blood 118:2653-655 CrossRef
  10. Iselius L, Carlson LA, Morton NE, Efendi? S, Lindsten J, Luft R (1985) Genetic and environmental determinants for lipoprotein concentrations in blood. Acta Med Scand 217:161-70 CrossRef
  11. Janipalli CS, Kumar MV, Vinay DG, Sandeep MN, Bhaskar S, Kulkarni SR, Aruna M, Joglekar CV, Priyadharshini S, Maheshwari N et al (2012) Analysis of 32 common susceptibility genetic variants and their combined effect in predicting risk of Type 2 diabetes and related traits in Indians. Diabet Med 29:121-27 CrossRef
  12. Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T et al (2009) Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 41:56-5 CrossRef
  13. Kim YJ, Go MJ, Hu C, Hong CB, Kim YK, Lee JY, Hwang JY, Oh JH, Kim DJ, Kim NH et al (2011) Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. Nat Genet 43:990-95 CrossRef
  14. Kumar MS, Hancock DC, Molina-Arcas M, Steckel M, East P, Diefenbacher M, Armenteros-Monterroso E, Lassailly F, Matthews N et al (2012) The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer.
• 刊物主题：Microbial Genetics and Genomics; Plant Genetics & Genomics; Animal Genetics and Genomics; Human Genetics;
• 出版者：Springer Netherlands
• ISSN：2092-9293

文摘

High triglyceride (TG) levels are known to be associated with complex diseases such as cardiovascular disease. Here, we evaluated the effect of interactions between genetic polymorphisms and environmental factors on plasma TG levels in a Korean aging cohort. Thirty-two single nucleotide polymorphism (SNP) markers located in seven genes (ADLH2, APOE, GCKR, MC4R, TCF7L2, GATA2, and HNF1A) for TG levels were genotyped in 714 older Koreans (mean age, 68?years). We performed multiple linear regression analyses for these SNP markers under three genetic models (i.e. additive, dominant, and recessive) and evaluated their associations with multiple environmental factors, including obesity, systolic blood pressure, and drinking and smoking habits. We found evidence for four SNP-smoking interactions. The CC genotype of rs1260326 (GCKR) interacted with current smoking for lower TG levels (P G×E?=?0.017). TG levels were higher in smokers with the GG genotype of rs2713604 (GATA2) than in those with the GA?+?AA genotypes (195.6 and 145.7?mg/dL, respectively, P G×E?=?0.029). The GA?+?AA genotypes of rs2713603 (GATA2) were associated with elevated TG levels in smokers when compared to non-smokers carrying the GG genotype (180.6?mg/dL vs. 148.3?mg/dL, P G×E?=?0.046). The C allele of rs2464196 (HNF1A) interacted with current smoking for elevated TG levels (P G×E?=?0.028). The gene and cigarette smoking interactions shown in this study need to be validated in a large-scale study.