Association between IL-17 and IgA in the joints of patients with inflammatory arthropathies
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- 作者：Ricardo Javier Eliçabe ; Juan Eduardo Silva ; Mabel Noemí Dave…
- 关键词：Interleukin ; 17 ; Immunoglobulin A ; Synovial fluid ; Transforming growth factor ; B ; cell activating factor of the TNF family
- 刊名：BMC Immunology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：18
- 期：1
- 全文大小：1269KB
- 刊物主题：Immunology; Allergology; Vaccine; Cytokines and Growth Factors;
- 出版者：BioMed Central
- ISSN：1471-2172
- 卷排序：18
文摘
BackgroundHyperactive secretion and pathogenic effects of interleukin (IL)-17 and IgA have been detected in different arthropathies. Recent evidence has revealed that TH17 cytokines regulate mucosal IgA secretion. However, it is unknown whether and how IL-17 mediates synovial IgA production. Here we aim to investigate the connection of synovial IL-17 with IgA production in the joint.