High salivary soluble L-selectin and interleukin-7 levels in Asian Indian patients with primary Sjögren’s syndrome

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• 作者：Jayakanthan Kabeerdoss ; Pulukool Sandhya ; Santosh Kumar Mandal…
• 关键词：Interleukin ; 7 ; Lymphotoxin ; α ; Saliva ; Sjögren’s syndrome ; Soluble L ; selectin
• 刊名：Clinical Rheumatology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：35
• 期：12
• 页码：3063-3067
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Rheumatology;
• 出版者：Springer London
• ISSN：1434-9949
• 卷排序：35

文摘

In present study, we aimed to study salivary soluble L-selectin (sL-selectin), interleukin-7(IjL-7), and lymphotoxin-α levels in primary Sjögren’s syndrome (pSS) and their clinical as well as serological correlations. pSS patients fulfilling either the American European Consensus Group (AECG) and/or the American college of Rheumatology (ACR) criteria were recruited. Age- and sex-matched hospital staff were recruited as healthy controls. Unstimulated saliva was collected by the spitting method; sL-selectin, IL-7, and lymphotoxin-α were measured in the saliva using commercial ELISA kits. Forty-three patients with pSS and 31 healthy controls were included in the study. Increased levels of sL-selectin and IL-7 were found in the saliva of patients as compared to controls. Lymphotoxin-α was undetectable in the saliva of pSS patients and controls. Salivary sL-selectin positively correlated with rheumatoid factor (r = 0.47; p < 0.003). No other variable including ESSDAI was significantly associated with salivary sL-selectin and IL-7 levels. Indian patients with primary Sjögren’s syndrome have higher salivary sL-selectin and IL-7 levels than healthy controls.