Fixed Versus Variable Dosing of Prothrombin Complex Concentrate in Vitamin K Antagonist-Related Intracranial Hemorrhage: A Retrospective Analysis
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- 作者：Rahat Amadkhan Abdoellakhan ; Ishita Parveen Miah ; Nakisa Khorsand…
- 关键词：Intracranial hemorrhage ; Hemostasis ; International normalized ratio ; Prothrombin complex concentrate ; Vitamin K antagonist
- 刊名：Neurocritical Care
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：26
- 期：1
- 页码：64-69
- 全文大小：437KB
- 刊物主题：Internal Medicine; Neurology; Intensive / Critical Care Medicine;
- 出版者：Springer US
- ISSN：1556-0961
- 卷排序：26
文摘
BackgroundMillions of patients receive vitamin K antagonist (VKA) therapy worldwide. Annually 0.2–1 % of all VKA users develops an intracranial hemorrhage (ICH). Prothrombin complex concentrate (PCC) is administered to restore the INR ≤ 1.5 in an attempt to limit hematoma growth. In order to facilitate PCC dosing, our hospital recently changed from a variable dose based on bodyweight, baseline- and target-INR, to a fixed 1000 IU fIX PCC dosing protocol for ICH.