Altered expression of IL36γ and IL36 receptor (IL1RL2) in the colon of patients with Hirschsprung’s disease

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• 作者：Christian Tomuschat ; Anne Marie O’Donnell ; David Coyle…
• 关键词：Hirschsprung’s disease ; IL36γ ; IL1RL2 ; Hirschsprung’s associated enterocolitis (HAEC) ; Inflammatory bowel disease
• 刊名：Pediatric Surgery International
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：33
• 期：2
• 页码：181-186
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Pediatrics; Surgery; Pediatric Surgery;
• 出版者：Springer Berlin Heidelberg
• ISSN：1437-9813
• 卷排序：33

文摘

PurposeHirschsprung’s disease associated enterocolitis (HAEC) is the most common cause of morbidity and mortality in Hirschsprung’s disease (HSCR). Altered intestinal epithelial barrier function and abnormal microbiota are implicated in the pathogenesis of HAEC. IL-36γ, a member of the IL-1 superfamily, is involved in host defense and contributes to proinflammatory responses and development of inflammatory diseases. The IL36 receptor (IL1RL2) is an important mediator molecule in the inflammatory response. Animal data suggests that IL1RL2 is involved in mucosal healing. We designed this study to investigate the hypothesis that the IL-36γ axis is altered in HSCR.