Modulatory Effects of Oral Bovine Lactoferrin on the IgA Response at Inductor and Effector Sites of Distal Small Intestine from BALB/c Mice

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• 作者：Ivonne Maciel Arciniega-Martínez…
• 关键词：Bovine lactoferrin ; IgA ; Intestinal modulation ; Ileum ; Peyer’s patches ; Intestinal lamina propria
• 刊名：Archivum Immunologiae et Therapiae Experimentalis
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：64
• 期：1
• 页码：57-63
• 全文大小：378 KB
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• 作者单位：Ivonne Maciel Arciniega-Martínez (1)
  Rafael Campos-Rodríguez (1)
  María Elisa Drago-Serrano (2)
  Luvia Enid Sánchez-Torres (3)
  Teresita Rocío Cruz-Hernández (1)
  Aldo Arturo Reséndiz-Albor (1)
  
  1. Research and Graduate Studies Section, Superior School of Medicine, National Polytechnic Institute, Plan de San Luis y Díaz Mirón s/n, Col. Santo Tomás, CP 11340, Mexico, DF, Mexico
  2. Department of Biological Systems, Autonomous Metropolitan University Campus Xochimilco, Calzada del Hueso No 1100, Col. Villa Quietud, CP 04960, Mexico, DF, Mexico
  3. Department of Immunology, National School of Biological Sciences, National Polytechnic Institute, Prolongación Carpio y Plan de Ayala s/n, Col. Santo Tomás, CP 11340, Mexico, DF, Mexico
  
• 刊物主题：Immunology; Pharmacology/Toxicology;
• 出版者：Springer Basel
• ISSN：1661-4917

文摘

Bovine lactoferrin (bLf) up-modulates intestinal IgA that is essential for homeostasis and which might confer protection to the distal small intestine that is vulnerable to inflammation. This study analyzed the effects of bLf administered orally on the IgA response at inductive (Peyer’s patches) and effector (lamina propria) sites of the distal small intestine in mice. Groups of five healthy male BALB/c mice were orally treated with 5 mg of bLf for 7, 14, 21, or 28 days. Then, mice were killed and the distal small intestine was dissected. Intestinal fluid samples were analyzed to determine IgA and IgM levels by enzyme-immuno assay. Peyer’s patches and lamina propria were analyzed for IgA+ or IgM+ plasma cells, B, CD4+ T and CD8+ T cells as well as CD4+ T cells positive for either pro-inflammatory cytokines [tumor necrosis factor (TNF)-α, interferon-γ and interleukin (IL)-12] or for IgA-producing ILs (IL-4, -5, -10 and -6) by cytofluorometry. Antibodies, antibody-secreting cells, and B and T responses in both Peyer’s patches and lamina propria were higher in bLf-treated than bLf-untreated mice. The generation of IL-10 and IL-6 CD4+ T cells in Peyer’s patches or TNF-α and IL-12 CD4+ T cells in lamina propria showed similar response patterns. On days 14 and 28, cytokine/IL CD4+ T cell responses were increased in Peyer’s patches or decreased in lamina propria. The effect of bLf on the elicitation of IgA indicates a potential application of bLf as a nutraceutical to control inflammation in the distal small intestine. Keywords Bovine lactoferrin IgA Intestinal modulation Ileum Peyer’s patches Intestinal lamina propria