Nonlinear transcriptomic response to dietary fat intake in the small intestine of C57BL/6J mice

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• 作者：Tenzin Nyima ; Michael Müller ; Guido J. E. J. Hooiveld ; Melissa J. Morine…
• 关键词：ABC transporters ; Acute ; phase response ; Cholesterol homeostasis ; Cholesterol transport and efflux ; Inflammatory response ; Small intestine absorption ; Transcriptomic response to fat intake
• 刊名：BMC Genomics
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：17
• 期：1
• 全文大小：1,076 KB
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• 作者单位：Tenzin Nyima (1)
  Michael Müller (2) (3)
  Guido J. E. J. Hooiveld (2)
  Melissa J. Morine (1)
  Marco Scotti (1) (4)
  
  1. The Microsoft Research - University of Trento Centre for Computational and Systems Biology, Rovereto, Italy
  2. Nutrition, Metabolism and Genomics group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
  3. Norwich Medical School, University of East Anglia, Norwich, UK
  4. GEOMAR Helmholtz Centre for Ocean Research, Kiel, Germany
  
• 刊物主题：Life Sciences, general; Microarrays; Proteomics; Animal Genetics and Genomics; Microbial Genetics and Genomics; Plant Genetics & Genomics;
• 出版者：BioMed Central
• ISSN：1471-2164

文摘

Background A high caloric diet, in conjunction with low levels of physical activity, promotes obesity. Many studies are available regarding the relation between dietary saturated fats and the etiology of obesity, but most focus on liver, muscle and white adipose tissue. Furthermore, the majority of transcriptomic studies seek to identify linear effects of an external stimulus on gene expression, although such an assumption does not necessarily hold. Our work assesses the dose-dependent effects of dietary fat intake on differential gene expression in the proximal, middle and distal sections of the small intestine in C57BL/6J mice. Gene expression is analyzed in terms of either linear or nonlinear responses to fat intake.