Effect of reducing iodine excess on children's goiter prevalence in areas with high iodine in drinking water

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• 作者：Shengmin Lv ; Lijun Xie ; Dong Xu ; Yuchun Wang ; Lihui Jia ; Yonggui Du
• 关键词：Body surface area ; Iodized salt ; Goiter ; Prevalence ; Drinking water
• 刊名：Endocrine
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：52
• 期：2
• 页码：296-304
• 全文大小：383 KB
• 参考文献：1.B. Hans, Iodine excess. Best Pract. Res. Clin. Endocrinol. Metab. 24(1), 107–115 (2010)CrossRef
  2.H.M. Shen, S.J. Liu, D.J. Sun, S. Zhang, X. Su, Y. Shen, H. Han, Geographical distribution of drinking-water with high iodine level and association between high iodine level in drinking-water and goitre: a Chinese national investigation. Br. J. Nutr. 106(2), 243–247 (2011)CrossRef PubMed
  3.M. Li, D.R. Liu, C.Y. Qu, P.Y. Zhang, Q.D. Qian, C.D. Zhang, Q.Z. Jia, H.X. Wang, C.J. Eastman, S.C. Boyages, Endemic goiter in Central China caused by excessive iodine intake. Lancet 2(8553), 257–259 (1987)PubMed
  4.J.K. Zhao, P. Wang, L. Shang, K.M. Sullivan, F. van der Haar, G. Maberly, Endemic goiter associated with high iodine intake. Am. J. Public Health 90(10), 1633–1635 (2000)CrossRef PubMed PubMedCentral
  5.S.M. Lv, J. Zhao, D. Xu, Z. Chong, L. Jia, Y. Du, J. Ma, S. Rutherford, An epidemiological survey of children’s iodine nutrition and goitre status in regions with mildly excessive iodine in drinking water in Hebei Province, China. Public Health Nutr. 15(7), 1168–1173 (2012)CrossRef PubMed
  6.S. Lv, D. Xu, Y. Wang, Z. Chong, Y. Du, L. Jia, J. Zhao, J. Ma, Goitre prevalence and epidemiological features in children living in areas with mildly excessive iodine in drinking-water. Br. J. Nutr. 111(1), 86–92 (2014)CrossRef PubMed
  7.M.B. Zimmermann, Iodine deficiency. Endocr. Rev. 30(4), 376–408 (2009)CrossRef PubMed
  8.S.R. Brahmbhatt, R.M. Brahmbhatt, S.C. Boyages, Thyroid ultrasound is the best prevalence indicator for assessment of iodine deficiency disorders: a study in rural/tribal schoolchildren from Gujarat (Western India). Eur. J. Endocrinol. 143(1), 37–46 (2000)CrossRef PubMed
  9.S. Peterson, A. Sanga, H. Eklöf, B. Bunga, A. Taube, M. Gebre-Medhin, H. Rosling, Classification of thyroid size by palpation and ultrasonography in field surveys. Lancet 355(9198), 106–110 (2000)CrossRef PubMed
  10.F. Delange, G. Benker, P. Caron, O. Eber, W. Ott, F. Peter, J. Podoba, M. Simescu, Z. Szybinsky, F. Vertongen, P. Vitti, W. Wiersinga, V. Zamrazil, Thyroid volume and urinary iodine in European schoolchildren: standardization of values for assessment of iodine deficiency. Eur. J. Endocrinol. 136(2), 180–187 (1997)CrossRef PubMed
  11.F. Xu, K. Sullivan, R. Houston, J. Zhao, W. May, G. Maberly, Thyroid volumes in US and Bangladeshi schoolchildren: comparison with European school children. Eur. J. Endocrinol. 140(6), 498–504 (1999)CrossRef PubMed
  12.B.K. Kim, Y.S. Choi, C.H. Oak, Y.H. Park, J.H. Kim, D.J. Park, C. Mora, D. Wilson, E.K. Park, Determination of thyroid volume by ultrasonography among schoolchildren in Philippines. Int. J. Endocrinol. (2012). doi:10.​1155/​2012/​387971
  13.WHO/UNICEF/ICCIDD, Assessment of Iodine Deficiency Disorders and Monitoring Their Elimination, 3rd edn. (WHO, Geneva, 2007)
  14.S.M. Lv, L.J. Xie, R.H. Zhou, Z.S. Chong, L.H. Jia, M.A. Jing, J. Zhao, D. Xu, Control of iodine deficiency disorders following 10-year universal salt iodization in Hebei province of China. Biomed. Environ. Sci. 22(6), 472–479 (2009)CrossRef PubMed
  15.D.R. Ma, R.H. Zhou, L.H. Jia, Survey on the distribution of the areas with excessive iodine in drinking water in Hebei plain. Chin J Control Endemic Dis 21(5), 237–238 (2006). (in Chinese)
  16.X.Y. Li, Estimation of sample size, in Health Statistics, ed. by Y.L. Ding, G. Gao (Science Publishing House, Beijing, 2008), pp. 126–132. (in Chinese)
  17.J. Brunn, U. Block, G. Ruf, I. Bos, W.P. Kunze, P.C. Scriba, Volumetric analysis of thyroid lobes by real-time ultrasound. Dtsch Med Wochenschr 106(41), 1338–1340 (1981). (in German) CrossRef PubMed
  18.Ministry of Health, Method for Determination of Iodine in Urine by As 3+ -Ce 4+ Catalytic Spectrophotometry (MOH, Beijing, 2006). (in Chinese)
  19.State Bureau of Quality and Technical Supervision, General Test Method in Salt Industry-Determination of Iodide Ion (SBQTS, Beijing, 1999). (in Chinese)
  20.Ministry of Health, The Standard Test Method for Drinking Water (MOH, Beijing, 2006). (in Chinese)
  21.WHO, Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ. Tech. Rep. Ser. 854, 1–452 (1995)
  22.M. Li, N. McKelleher, T. Moses, J. Mark, K. Byth, G. Ma, C.J. Eastman, Iodine nutritional status of children on the island of Tanna, Republic of Vanuatu. Public Health Nutr. 12(9), 1512–1518 (2009)CrossRef PubMed
  23.S. Henjum, I. Barikmo, A.K. Gjerlaug, A. Mohamed-Lehabib, A. Oshaug, T.A. Strand, L.E. Torheim, Endemic goitre and excessive iodine in urine and drinking water among Saharawi refugee children. Public Health Nutr. 13(9), 1472–1477 (2010)CrossRef PubMed
  24.M.B. Zimmermann, Y. Ito, S.Y. Hess, K. Fujieda, L. Molinari, High thyroid volume in children with excess dietary iodine intakes. Am. J. Clin. Nutr. 81(4), 840–844 (2005)PubMed
  25.F. Azizi, M. Malik, E. Bebars, H. Delshad, A. Bakir, Thyroid volumes in schoolchildren of the Emirates. J. Endocrinol. Invest. 26(1), 56–60 (2003)CrossRef PubMed
  26.B. Busnardo, D. Nacamulli, F. Frigato, A. Vianello-Dri, D. De Vido, C. Mian, F. Candiani, G. Tomasella, L. Zambonin, M. Piccolo, M.E. Girelli, Normal values for thyroid ultrasonography, goiter prevalence and urinary iodine concentration in schoolchildren of the Veneto Region Italy. J. Endocrinol. Invest. 26(10), 991–996 (2003)CrossRef PubMed
  27.S. Andersen, S.B. Petersen, P. Laurberg, Iodine in drinking water in Denmark is bound in humic substances. Eur. J. Endocrinol. 147(5), 663–670 (2002)CrossRef PubMed
  28.S. Andersen, H. Guan, W. Teng, P. Laurberg, Speciation of iodine in high iodine groundwater in china associated with goitre and hypothyroidism. Biol. Trace Elem. Res. 128(2), 95–103 (2009)CrossRef PubMed
  29.T.S. Huang, F.J. Lu, C.W. Tsai, I.J. Chopra, Effect of humic acids on thyroidal function. J. Endocrinol. Invest. 17(10), 787–791 (1994)CrossRef PubMed
  30.C.S. Zhu, Q.L. Wang, H.Y. Wu, Observation on the prognosis of goiter caused by high iodine intake after changing water source. Chin. J. Endem. 21(3), 186 (2002). (in Chinese)
  31.P.H. Wang, Q.L. Zhang, L. Shang, Analysis on the relationship between variation of schoolchildren’s goiter prevalence and changing drinking water source in high iodine area after stopping iodized salt supply. Chin. Preli. Health Care 19(1), 61–62 (2005). (in Chinese)
  
• 作者单位：Shengmin Lv (1)
  Lijun Xie (1)
  Dong Xu (1)
  Yuchun Wang (2)
  Lihui Jia (1)
  Yonggui Du (1)
  
  1. Hebei Province Center for Disease Prevention and Control, No. 97, Huai’an Donglu, Shijiazhuang, 050021, Hebei, China
  2. Hengshui Municipal Center for Disease Prevention and Control, Hengshui, China
  
• 刊物主题：Endocrinology; Diabetes; Internal Medicine; Science, general;
• 出版者：Springer US
• ISSN：1559-0100

文摘

The purpose of the study was to evaluate the effect of removing iodized salt on children’s goiter prevalence in high iodine area (HIA). A total of 452 and 459 children aged 8–10 years old were selected by simple random sampling method before and after removing iodized salt from their diet in three towns with median water iodine content of 150–300 µg/l in Hengshui city of Hebei province of China. Their goiter status was judged using the thyroid volume (Tvol) reference for body surface area recommended by the WHO. After removing iodized salt, children’s overall median urinary iodine content (MUIC) decreased from 518 (IQR 347,735) µg/l to 416 µg/l (IQR 274,609). Children’s MUIC across sex and age group decreased significantly. The overall goiter prevalence in the three towns significantly decreased from 32.96 % (149/452) to 6.54 % (30/459) (P < 0.001). The goiter prevalence in 8-, 9-, and 10-year-old children decreased, respectively, from 38.04 % (35/92), 30.57 % (59/193), and 32.93 % (55/167) to 6.10 % (10/164), 6.75 % (11/163), and 6.82 % (9/132). The goiter prevalence in boys and girls decreased from 34.01 % (83/244) and 31.73 % (66/208) to 6.19 % (14/225) and 6.87 % (16/234), respectively. The decreases in children’s goiter prevalence across gender and age groups were all statistically significant. The present study revealed that children’s goiter prevalence decreased significantly after removing iodized salt from their diet for about one and half years in the HIA in Hebei province.