Clinical correlation of the binding potential with ¹²³I-FP-CIT in de novo idiopathic Parkinson¡¯s disease patients

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• 作者：Valentina Berti ; Alberto Pupi ; Silvia Ramat ; Eleonora Vanzi ; Maria Teresa De Cristofaro ; Giannantonio Pellican¨° ; Francesco Mungai ; Paolo Marini and Sandro Sorbi
• 关键词：123I ; FP ; CIT ; Binding potential ; Parkinson’ ; s disease ; Severity ; Biomarker
• 刊名：European Journal of Nuclear Medicine and Molecular Imaging
• 出版年：2008
• 出版时间：December, 2008
• 年：2008
• 卷：35
• 期：12
• 页码：2220-2226
• 全文大小：314.7 KB

文摘

Purpose The aim of this study was to evaluate the accuracy of different single-photon emission computed tomography (SPECT) reconstruction techniques in measuring striatal N-ω-fluoropropyl-2 46;-carbomethoxy-3 46;-4-[123I]iodophenyl-nortropane (123I-FP-CIT) binding in de novo Parkinson’s disease (PD) patients, in order to find a correlation with clinical scales of disease severity in the initial phases of disease.