Highly accurate scattering spectra of strongly absorbing samples obtained using an integrating sphere system by considering the angular distribution of diffusely reflected light

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• 作者：D. Fukutomi ; K. Ishii ; K. Awazu
• 关键词：Integrating sphere ; Inverse Monte Carlo simulation ; Optical property ; Scattering coefficient ; Diffuse reflectance ; Entrance port diameter
• 刊名：Lasers in Medical Science
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：30
• 期：4
• 页码：1335-1340
• 全文大小：1,311 KB
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• 作者单位：D. Fukutomi (1)
  K. Ishii (1)
  K. Awazu (1) (2) (3)
  
  1. Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan
  2. Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka, 565-0871, Japan
  3. The Center for Advanced Medical Engineering and Informatics, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Medicine/Public Health, general
  Dentistry
  Laser Technology and Physics and Photonics
  Quantum Optics, Quantum Electronics and Nonlinear Optics
  Applied Optics, Optoelectronics and Optical Devices
  
• 出版者：Springer London
• ISSN：1435-604X

文摘

An integrating sphere system has been used to investigate the estimation error in the scattering coefficient for biological tissues. Since the angular distribution of diffusely reflected light from a sample may depend on the sample absorbance, leakage at the entrance port may affect estimates of the scattering coefficient based on measurement of diffuse reflectance. In the present study, the dependence of the angular distribution of the diffusely reflected light on the hemoglobin (Hb) concentration in a sample was investigated. Subsequently, the effect of the entrance port diameter on the error in the scattering coefficient estimated based on diffuse reflectance measurements was evaluated. For a biological tissue phantom, the angular reflectance distribution at a wavelength of 405?nm, at which strong absorption occurred, showed an increasing bias toward specular reflection as the Hb concentration was increased. No such concentration dependence was found at a wavelength of 664?nm, where the absorbance was low. In addition, it was found that the estimation error in the scattering coefficient was reduced for smaller entrance port diameters. Therefore, when attempting to determine the scattering coefficient for strongly absorbing samples, it is necessary to consider both the angular distribution of the diffusely reflected light and the optimal entrance port diameter.