Vitamin D in the General Population of Young Adults with Autism in the Faroe Islands
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- 作者：Eva Ko?ovská (1) (2)
Guerie Andorsdóttir (3)
Pál Weihe (4)
Jónrit Halling (4)
Elisabeth Fernell (1) (5)
Tormóeur Stóra (6)
Rannvá Biskupst? (3)
I. Carina Gillberg (1)
Robyn Shea (7)
Eva Billstedt (1)
Thomas Bourgeron (10) (8) (9)
Helen Minnis (2)
Christopher Gillberg (1) - 关键词：Autism ; ASD ; Vitamin D ; Calcitriol ; Total population ; Faroe Islands
- 刊名：Journal of Autism and Developmental Disorders
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：44
- 期：12
- 页码：2996-3005
- 全文大小：296 KB
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Guerie Andorsdóttir (3)
Pál Weihe (4)
Jónrit Halling (4)
Elisabeth Fernell (1) (5)
Tormóeur Stóra (6)
Rannvá Biskupst? (3)
I. Carina Gillberg (1)
Robyn Shea (7)
Eva Billstedt (1)
Thomas Bourgeron (10) (8) (9)
Helen Minnis (2)
Christopher Gillberg (1)
1. Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Kungsgatan 12, 411 19, G?teborg, Sweden
2. Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, Caledonia House, Royal Hospital for Sick Children, University of Glasgow, Glasgow, G3 8SJ, UK
3. Genetic Biobank of the Faroes, Ministry of Health, J.C. Svabosg?ta 43, 100, Tórshavn, Faroe Islands
4. Department of Occupational Medicine and Public Health, Faroese Hospital System, Sigmundarg?ta 5, 100, Tórshavn, Faroe Islands
5. Research and Development Centre, Skaraborgs Hospital, 541 85, Sk?vde, Sweden
6. Psychiatric Center, The National Hospital of the Faroe Islands, J.C. Svabosg?ta, 100, Tórshavn, Faroe Islands
7. Clinical Biochemistry Department, City Hospital, Sandwell and West Birmingham Hospitals, NHS Trust, Dudley Road, Birmingham, B18 7QH, UK
10. Human Genetics and Cognitive Functions, Sorbonne Paris Cité, University Paris Diderot, Paris, France
8. Human Genetics and Cognitive Functions Unit, Institute Pasteur, Paris, France
9. CNRS URA 2182 Genes, Synapses and Cognition, Institut Pasteur, Paris, France - ISSN：1573-3432
文摘
Vitamin D deficiency has been proposed as a possible risk factor for developing autism spectrum disorder (ASD). 25-Hydroxyvitamin D3 (25(OH)D3) levels were examined in a cross-sectional population-based study in the Faroe Islands. The case group consisting of a total population cohort of 40 individuals with ASD (aged 15-4?years) had significantly lower 25(OH)D3 than their 62 typically-developing siblings and their 77 parents, and also significantly lower than 40 healthy age and gender matched comparisons. There was a trend for males having lower 25(OH)D3 than females. Effects of age, month/season of birth, IQ, various subcategories of ASD and Autism Diagnostic Observation Schedule score were also investigated, however, no association was found. The very low 25(OH)D3 in the ASD group suggests some underlying pathogenic mechanism.