Vasostatin-1 Stops Structural Remodeling and Improves Calcium Handling via the eNOS-NO-PKG Pathway in Rat Hearts Subjected to Chronic β-Adrenergic Receptor Activation
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- 作者：Dandan Wang ; Yingguang Shan ; Yan Huang ; Yanhong Tang…
- 关键词：Vasostatin ; 1 ; Isoprenaline ; Cardiac remodeling ; Left ventricular function ; Ca2+ handling
- 刊名：Cardiovascular Drugs and Therapy
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：30
- 期：5
- 页码：455-464
- 全文大小：3,305 KB
- 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Cardiology - 出版者：Springer Netherlands
- ISSN：1573-7241
- 卷排序：30
文摘
PurposeChronically elevated catecholamine levels activate cardiac β-adrenergic receptors, which play a vital role in the pathogenesis of heart failure. Evidence suggests that vasostatin-1 (VS-1) exerts anti-adrenergic effects on isolated and perfused hearts in vitro. Whether VS-1 ameliorates hypertrophy/remodeling by inducing the chronic activation of β-adrenergic receptors is unknown. The present study aims to test the efficacy of using VS-1 to treat the advanced hypertrophy/remodeling that result from chronic β-adrenergic receptor activation and to determine the cellular and molecular mechanisms that underlie this response.