Resistance to oral antibiotics in 4569 Gram-negative rods isolated from urinary tract infection in children
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- 作者：Anna Calzi ; Sara Grignolo ; Ilaria Caviglia…
- 关键词：Oral antibiotics ; Gram ; negative rods ; Urinary tract infection ; Children
- 刊名：European Journal of Pediatrics
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：175
- 期：9
- 页码：1219-1225
- 全文大小：293 KB
- 刊物主题：Pediatrics;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-1076
- 卷排序：175
文摘
To investigate antibiotic resistance among pathogens isolated from urines in a tertiary care children’s hospital in Italy. Retrospective analysis of prospectively collected data on antibiotic susceptibility of Gram-negatives isolated from urines at the Istituto Giannina Gaslini, Genoa - Italy from 2007 to 2014. Antibiotic susceptibility was evaluated. By means of CLSI criteria from 2007 to 2010, while from 2011 EUCAST criteria were adopted. Data on susceptibility to amoxicillin-clavulanate, co-trimoxazole, cefuroxime, nitrofurantoin, fosfomycin and ciprofloxacin were evaluated for Escherichia coli, while for other Enterobacteriaceae data were collected for amoxicillin-clavulanate, co-trimoxazole and ciprofloxacin and for ciprofloxacin against Pseudomonas aeruginosa. Univariate and multivariable analyses were performed for risk factors associated with resistance. A total of 4596 Gram-negative strains were observed in 3364 patients. A significant increase in the proportion of resistant strains was observed for E.coli against amoxicillin-clavulanate, cefuroxime and ciprofloxacin and for others Enterobacteriaceae against co-trimoxazole and ciprofloxacin. Resistance to nitrofurantoin and fosfomycin was very infrequent in E.coli. Logistic regression analysis showed that repeated episode of urinary tract infections was a risk factor for E.coli resistance to amoxicillin-clavulanate, co-trimoxazole and cefuroxime, while admission in one of the Units usually managing children with urinary tract malformations was significantly associated to resistance to amoxicillin-clavulanate and cefuroxime.