Fatigue, Depression, Sleep, and Activity During Chemotherapy: Daily and Intraday Variation and Relationships Among Symptom Changes

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• 作者：Heather S. L. Jim Ph.D. (1)
  Brent Small Ph.D. (2)
  Leigh Anne Faul Ph.D. (3)
  Jamie Franzen B.A (2)
  Sachin Apte M.D. (1)
  Paul B. Jacobsen Ph.D. (1)
  
• 关键词：Gynecologic cancer ; Fatigue ; Depression ; Actigraphy ; Sleep ; Chemotherapy
• 刊名：Annals of Behavioral Medicine
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：42
• 期：3
• 页码：321-333
• 全文大小：281KB
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• 作者单位：Heather S. L. Jim Ph.D. (1)
  Brent Small Ph.D. (2)
  Leigh Anne Faul Ph.D. (3)
  Jamie Franzen B.A (2)
  Sachin Apte M.D. (1)
  Paul B. Jacobsen Ph.D. (1)
  
  1. Moffitt Cancer Center, 12902 Magnolia Drive MRC-PSY, Tampa, FL, 33612, USA
  2. University of South Florida, Tampa, FL, USA
  3. Georgetown University, Washington DC, USA
  

文摘

Background Previous research suggests that cancer patients frequently experience multiple symptoms during chemotherapy; however, relationships among symptom changes are largely unknown. Purpose The aim of the current study was to examine daily and intraday changes and interrelationships among fatigue, depression, and objectively measured disruptions in sleep and activity during chemotherapy. Methods Participants were 78 women with gynecologic cancer. Fatigue, depression, sleep, and activity were assessed the week before and the week after the participants-first three infusions. Results Significant changes in fatigue, depression, sleep, and activity were observed over time. Before infusions, increases in fatigue were associated with increases in depression. After infusions, increases in fatigue were associated with increases in depression and minutes awake at night, as well as decreases in daytime activity and regularity of sleep/activity patterns (ps-lt;-05). Conclusions This study is among the first to track daily and intraday changes in symptoms and interrelationships during chemotherapy. Results indicate that symptoms are interrelated and return to baseline levels after infusions.