Can selenium levels act as a marker of colorectal cancer risk?
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- 作者：Marcin R Lener (1)
Satish Gupta (1) (2)
Rodney J Scott (3) (4)
Martin Tootsi (5)
Maria Kulp (6)
Mari-Liis Tammesoo (5)
Anu Viitak (6)
Anders Metspalu (5)
Pablo Serrano-Fernández (1)
Józef K?adny (7)
Katarzyna Jaworska-Bieniek (1) (2)
Katarzyna Durda (1)
Magdalena Muszyńska (1)
Grzegorz Sukiennicki (1)
Anna Jakubowska (1)
Jan Lubiński (1) - 关键词：Selenium ; Colorectal ; Cancer risk ; Dietary supplement
- 刊名：BMC Cancer
- 出版年：2013
- 出版时间：December 2013
- 年：2013
- 卷：13
- 期：1
- 全文大小：209KB
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24. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/13/214/prepub - 作者单位：Marcin R Lener (1)
Satish Gupta (1) (2)
Rodney J Scott (3) (4)
Martin Tootsi (5)
Maria Kulp (6)
Mari-Liis Tammesoo (5)
Anu Viitak (6)
Anders Metspalu (5)
Pablo Serrano-Fernández (1)
Józef K?adny (7)
Katarzyna Jaworska-Bieniek (1) (2)
Katarzyna Durda (1)
Magdalena Muszyńska (1)
Grzegorz Sukiennicki (1)
Anna Jakubowska (1)
Jan Lubiński (1)
1. Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Po?abska 4, 70-115, Szczecin, Poland
2. Postgraduate School of Molecular Medicine Medical University of Warsaw, ?wirki i Wigury 61, 02-091, Warsaw, Poland
3. Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Newcastle, NSW, 2308, Australia
4. The Hunter Medical Research Institute, Newcastle, NSW, 2308, Australia
5. The Estonian Genome Center, University of Tartu, 23b Riia Str, Tartu, 51010, Estonia
6. Department of Analytical Chemistry, Tallinn University of Technology, Akadeemia tee 1512618, Tallinn, Estonia
7. Department of General and Oncological Surgery, Pomeranian Medical University, Al. Powstańców Wlkp. 72, 70-111, Szczecin, Poland - ISSN：1471-2407
文摘
Background Selenium has attracted attention because of its antioxidant properties. Antioxidants protects cells from damage. Certain breakdown products of selenium are believed to prevent tumor growth by enhancing the immune cell activity and suppressing the development of tumor blood vessels. In this observational study, selenium level was measured in a series of patients from Poland and Estonia to determine a correlation between levels of this microelement and colorectal cancer risk. Methods A total of 169 colorectal cancer patients and 169 healthy controls were enrolled in the study after obtaining their informed consent. Selenium level in the blood serum was measured using Graphite Furnace Atomic Absorption Spectrometry (GFAAS). The statistical analysis was performed by Fisher’s exact test. Results The threshold point of selenium level was 55 μg/l and 65 μg/l for Poland and Estonia respectively, for an increase in cancer risk. The lower levels of selenium were associated with greater risk of colorectal cancer. Conclusions The result reveals a significant strong association between low selenium level and the colorectal cancer risk in both Estonian and Polish populations.