Serum copeptin levels in adolescents with primary hypertension

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• 作者：Edyta Tenderenda-Banasiuk (1)
  Anna Wasilewska (1)
  Renata Filonowicz (1)
  Urszula Jakubowska (2)
  Marlena Waszkiewicz-Stojda (1)
  
• 关键词：Adolescents ; Copeptin ; Hypertension
• 刊名：Pediatric Nephrology
• 出版年：2014
• 出版时间：March 2014
• 年：2014
• 卷：29
• 期：3
• 页码：423-429
• 全文大小：208 KB
• 作者单位：Edyta Tenderenda-Banasiuk (1)
  Anna Wasilewska (1)
  Renata Filonowicz (1)
  Urszula Jakubowska (2)
  Marlena Waszkiewicz-Stojda (1)
  
  1. Department of Pediatrics and Nephrology, Medical University of Bialystok, 17 Waszyngton Street, 15-274, Bialystok, Poland
  2. Emergency Department, Medical University of Bialystok, Bialystok, Poland
  
• ISSN：1432-198X

文摘

Background The prevalence of hypertension continues to rise in the pediatric population. In recent years, there has been an increasing amount of reports on serum arginine vasopressin and its derivative, copeptin, in blood pressure control, but its role is still unclear. The objective of this study was to assess serum copeptin in adolescents with essential hypertension. Methods The study cohort consisted of 84 subjects (30 girls and 54 boys) aged 11-8?years, divided into two groups: hypertension (HT) -53 subjects with confirmed primary hypertension and R - reference group -31 subjects in whom hypertension was excluded on the basis of ambulatory blood pressure monitoring (ABPM) (white-coat hypertension). Serum copeptin concentration was measured using a commercially available enzyme-linked immunosorbent assay kit (USCN). Results Hypertensive patients had higher serum copeptin levels (median, 267 [Q1–Q3: 151.1-99.7?pg/ml]) than controls (median, 107.3 [Q1–Q3: 36.7-03.4?pg/ml]), (p-lt;-.01). Statistically significant difference was found both in males and females. In both groups, positive correlations between serum copeptin and uric acid levels (r--.31, p-lt;-.01), albuminuria (r--.45, p-lt;-.01), serum triglycerides (r--.3, p-lt;-.05), body mass index (BMI) standard deviation score (SDS) (r--.24, p-lt;-.05) and 24-h systolic blood pressure (SBP) (r--.37, p-lt;-.01) and diastolic blood pressure (DBP) (r--.23, p-lt;-.05) were found. Conclusions In summary, higher serum copeptin levels, a surrogate for arginine vasopressin (AVP) release, are associated not only with systolic and diastolic blood pressure but also with several components of metabolic syndrome including obesity, elevated concentration of triglycerides, albuminuria, and serum uric acid level. However, for the time being, more research is needed in order to confirm the role of serum copeptin as a novel marker of elevated blood pressure and predictor of metabolic syndrome.