microRNA (miRNA)-Mediated Pathogenetic Signaling in Alzheimer's Disease (AD)

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• 作者：James M. Hill ; Walter J. Lukiw
• 关键词：Alzheimer’s disease (AD) ; AD diagnostics ; microRNA (miRNA) ; non ; coding RNA (ncRNA) ; RNA complexity ; Viroids
• 刊名：Neurochemical Research
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：41
• 期：1-2
• 页码：96-100
• 全文大小：373 KB
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• 作者单位：James M. Hill (1) (2)
  Walter J. Lukiw (1) (2) (3)
  
  1. LSU Neuroscience Center of Excellence, Louisiana State University Health Science Center, New Orleans, LA, 70112-2272, USA
  2. Department of Ophthalmology, LSU Neuroscience Center, Louisiana State University Health Science Center, New Orleans, LA, 70112, USA
  3. Department of Neurology, LSU Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 904, New Orleans, LA, 70112-2272, USA
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Biochemistry
  Neurology
  
• 出版者：Springer Netherlands
• ISSN：1573-6903

文摘

Alzheimer’s disease (AD) is an expanding health and socioeconomic concern in industrialized societies, and the leading cause of intellectual impairment in our aging population. The cause of AD remains unknown, and there are currently no effective treatments to stop or reverse the progression of this uniquely human and age-related neurological disorder. Elucidation of the AD mechanism and factors that contribute to the initiation, progression, and spreading of this chronic and fatal neurodegeneration will ultimately result in improved and effective diagnostics and therapeutic strategies.