From fission to fusion: A perspective on the research that won the Nobel Prize in Physiology or Medicine, 2013

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• 作者：Krishanu Ray
• 关键词：Budding ; COPI ; COPII ; fission ; fusion ; Nobel Prize 2013 ; NSF ; SNARE ; Vesicle traffic
• 刊名：Journal of Biosciences
• 出版年：2014
• 出版时间：March 2014
• 年：2014
• 卷：39
• 期：1
• 页码：3-11
• 全文大小：
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• 作者单位：Krishanu Ray (1)
  
  1. Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, 400 005, India
  
• 刊物类别：Life Sciences, general; Biomedicine general; Zoology; Plant Sciences; Microbiology; Cell Biology;
• 刊物主题：Life Sciences, general; Biomedicine general; Zoology; Plant Sciences; Microbiology; Cell Biology;
• 出版者：Springer India
• ISSN：0973-7138

文摘

Secretion is widespread in all eukaryotic cells: all of us experience this in the course of daily life 鈥?saliva, mucus, sweat, tears, bile juice, adrenalin, etc. 鈥?the list is extremely long. How does a cell manage to repeatedly spit out some stuff without losing the rest? The answer is: through regulated vesicle trafficking within the cell. The Nobel Prize in Physiology or Medicine 2013 was awarded to Drs Randy Schekman, James E Rothman and Thomas C S眉dhof for their 鈥榙iscoveries of machinery regulating vesicle traffic, a major transport system in our cells鈥? Dr Randy Schekman and his colleagues discovered a number of genes required for vesicle trafficking from the endoplasmic reticulum (ER) and Golgi; the James E Rothman group unravelled the protein machinery that allows vesicles to bud off from the membrane and fuse to their targets; and Dr Thomas C S眉dhof along with his colleagues revealed how calcium ions could instruct vesicles to fuse and discharge their contents with precision. These enabled the biotechnology industry to produce a variety of pharmaceutical and industrial products like insulin and hepatitis B vaccines, in a cost-efficient manner, using yeast and tissue cultured cells. Keywords Budding COPI COPII fission fusion Nobel Prize 2013 NSF SNARE Vesicle traffic