Development of animal model for Bisphosphonates-related osteonecrosis of the jaw (BRONJ)

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• 作者：Hyo-Won Jang ; Jin-Woo Kim ; In-Ho Cha
• 关键词：Bisphosphonates ; Osteonecrosis of the jaw ; Steroid ; Rat model
• 刊名：Maxillofacial Plastic and Reconstructive Surgery
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：37
• 期：1
• 全文大小：1300KB
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• 作者单位：Hyo-Won Jang (1)
  Jin-Woo Kim (2)
  In-Ho Cha (1) (3)
  
  1. Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul, South Korea
  2. Department of Oral and Maxillofacial Surgery, Mok-dong Hospital, Ewha Womans University, Seoul, South Korea
  3. Department of Oral and Maxillofacial Surgery and Oral Cancer Research Institute, College of Dentistry, Yonsei University, 250 Seongsanno, Seodaemun-gu, Seoul, 120-752, Republic of Korea
  
• 刊物类别：Dentistry; Oral and Maxillofacial Surgery; Plastic Surgery;
• 刊物主题：Dentistry; Oral and Maxillofacial Surgery; Plastic Surgery;
• 出版者：Springer Berlin Heidelberg
• ISSN：2288-8586

文摘

Background The aim of this study is to develop a rat model of bisphosphonates-related osteonecrosis of the jaw (BRONJ) that would be verified with clinical, radiological and histological examination, and to confirm the influence of concurrent bisphosphonates and steroids use upon the occurrence and aggravation of BRONJ.