Enhanceosome transcription factors preferentially dimerize with high mobility group proteins

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• 作者：Aleksander Jankowski ; Paulina Obara ; Utsav Mathur ; Jerzy Tiuryn
• 关键词：Enhanceosome ; Transcription factors ; Dimerization ; High mobility group genes ; Enhancers
• 刊名：BMC Systems Biology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：10
• 期：1
• 全文大小：2,147 KB
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• 作者单位：Aleksander Jankowski (1) (3)
  Paulina Obara (2)
  Utsav Mathur (1)
  Jerzy Tiuryn (1)
  
  1. Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Banacha 2, Warsaw, 02-097, Poland
  3. Current address: Genome Biology Unit, European Molecular Biology Laboratory, Meyerhofstraße 1, Heidelberg, 69117, Germany
  2. Faculty of Mathematics and Computer Science, Jagiellonian University, Łojasiewicza 6, Kraków, 30-348, Poland
  
• 刊物主题：Bioinformatics; Systems Biology; Simulation and Modeling; Computational Biology/Bioinformatics; Physiological, Cellular and Medical Topics; Algorithms;
• 出版者：BioMed Central
• ISSN：1752-0509

文摘

Background The enhanceosome is an enhancer located upstream of the human interferon β gene, bound by transcription factor (TF) complex of extremely rigid structure. Within these rigid constraints, even a slight change of distances between transcription factor binding sites (TFBS) results in loss of functionality of the enhanceosome. We hypothesized that smaller subunits of the enhanceosome may entail TF complex formation in other regulatory regions.