Solid Lipid Nanoparticles Enhance the Delivery of the HIV Protease Inhibitor, Atazanavir, by a Human Brain Endothelial Cell Line
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- 作者：Niladri Chattopadhyay ; Jason Zastre ; Ho-Lun Wong ; Xiao Yu Wu and Reina Bendayan
- 关键词：KEY WORDS atazanavir ; drug delivery ; hCMEC/D3 human brain microvessel endothelial cells ; HIV ; protease inhibitor ; solid lipid nanoparticles
- 刊名：Pharmaceutical Research
- 出版年：2008
- 出版时间：October, 2008
- 年：2008
- 卷：25
- 期：10
- 页码：2262-2271
- 全文大小：309.1 KB
文摘
Purpose Protease inhibitors (PIs) exhibit low brain permeability. As a result, unchallenged HIV viral replication can lead to HIV-encephalitis and antiretroviral drug resistance. The objective of this study was to develop and evaluate a lipid nanoparticle system for enhanced brain delivery of the potent and frequently used HIV PI, atazanavir, using a well characterized human brain microvessel endothelial cell line (hCMEC/D3) representative of the blood-brain barrier.