The pharmacokinetics of erythropoietin in the cerebrospinal fluid after intravenous administration of recombinant human erythropoietin
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- 作者：Anargyros Xenocostas ; Wing K. Cheung ; Francis Farrell ; Cindy Zakszewski ; Marian Kelley ; Andrzej Lutynski ; Michael Crump ; Jeffrey H. Lipton ; Thomas L. Kiss and Catherine Y. Lau ; et al.
- 关键词：Erythropoietin ; Blood– ; brain barrier ; Cerebrospinal fluid ; Neuroprotective agents
- 刊名：European Journal of Clinical Pharmacology
- 出版年：2005
- 出版时间：May 2005
- 年：2005
- 卷：61
- 期：3
- 页码：189-195
- 全文大小：256 KB
文摘
Objectives Erythropoietin (EPO) was originally described as a regulator of erythropoiesis. Recently, synthesis of EPO and expression of the EPO receptor (EPO-R) have been reported for the central nervous system (CNS). The potential use of EPO to prevent or reduce CNS injury and the paucity of information regarding its entry into the human CNS led us to examine the pharmacokinetics (PK) of recombinant human EPO (r-HuEPO) in the serum and cerebrospinal fluid (CSF).