Elevated HbA1c levels and the accumulation of differentiated T cells in CMV+ individuals

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• 作者：Jerrald L. Rector ; G. Neil Thomas ; Victoria E. Burns ; Jennifer B. Dowd…
• 关键词：Cholesterol ; CMV ; Cytomegalovirus ; Diabetes ; Glucose ; Haemoglobin A1c ; HbA1c ; Immune ageing ; Metabolic syndrome ; T cell
• 刊名：Diabetologia
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：58
• 期：11
• 页码：2596-2605
• 全文大小：354 KB
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• 作者单位：Jerrald L. Rector (1) (2)
  G. Neil Thomas (3)
  Victoria E. Burns (1)
  Jennifer B. Dowd (4) (5)
  Raphael M. Herr (2)
  Paul A. Moss (6)
  Marc N. Jarczok (2)
  Kristina Hoffman (2)
  Joachim E. Fischer (2)
  Jos A. Bosch (2) (7)
  
  1. School of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Birmingham, UK
  2. Mannheim Institute of Public Health, Social and Preventive Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany
  3. School of Health and Population Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
  4. CUNY School of Public Health, New York, NY, USA
  5. CUNY Institute for Demographic Research, New York, NY, USA
  6. Cancer Research UK Centre, University of Birmingham, Birmingham, UK
  7. Department of Psychology, University of Amsterdam, Weesperplein 4, 1018 XA, Amsterdam, The Netherlands
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428

文摘

Aims/hypothesis Biological ageing of the immune system, or immunosenescence, predicts poor health and increased mortality. A hallmark of immunosenescence is the accumulation of differentiated cytotoxic T cells (CD27?/sup>CD45RA+/?/sup>; or dCTLs), partially driven by infection with the cytomegalovirus (CMV). Immune impairments reminiscent of immunosenescence are also observed in hyperglycaemia, and in vitro studies have illustrated mechanisms by which elevated glucose can lead to increased dCTLs. This study explored associations between glucose dysregulation and markers of immunosenescence in CMV+ and CMV?/sup> individuals.