Polyethylenimine-poly(amidoamine) dendrimer modified with l-arginines as an efficient gene delivery vector
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- 作者：Nan Young Ahn ; Tae-Hun Kim ; Su Jeong Song ; Jeong-Mi Moon…
- 关键词：dendrimer ; polyethylenimine ; poly(amidoamine) ; L ; arginine ; nanoparticles
- 刊名：Macromolecular Research
- 出版年：2015
- 出版时间：August 2015
- 年：2015
- 卷：23
- 期：8
- 页码：726-733
- 全文大小：778 KB
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Tae-Hun Kim (1)
Su Jeong Song (1)
Jeong-Mi Moon (1)
Tai Hwan Ha (3)
Joon Sig Choi (1) (2)
1. Department of Biochemistry, Chungnam National University, Daejeon, 305-764, Korea
3. Future Biotechnology Research Division, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Daejeon, 305-806, Korea
2. Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, 305-764, Korea - 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Physical Chemistry
Polymer Sciences
Characterization and Evaluation of Materials
Soft and Granular Matter, Complex Fluids and Microfluidics
Nanochemistry
Nanotec - 出版者：The Polymer Society of Korea, co-published with Springer
- ISSN：2092-7673
文摘
In this study, we synthesized polyethylenimine-polyamidoamine-arginine dendritic polymers (PPRs) as vectors for gene delivery. Four polymers, polyethylenimine-polyamidoamine generation 1 (PP1), PP2, PP1-arginine (PP1R), and PP2-arginine (PP2R), were synthesized and confirmed by 1H NMR. PPRs were shown to interact with and condense plasmid DNA effectively to form 171-179 nm polyplexes with 30-32 mV of zeta potentials at weight ratio 4:1 (polymer:plasmid DNA). Cytotoxicity of PPRs/pDNA complexes was lower than that of polyethylenimine (PEI) 25 kDa/pDNA complexes for all concentration ranges tested. In 293 cells, PP1R/pDNA complexes showed higher gene transfection efficiency than PEI 25 kDa. These results suggest that PPR could be promising dendritic gene carriers for gene therapy.