Nanoplasmonic biopatch for in vivo surface enhanced raman spectroscopy

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• 作者：Sang-Gil Park (1)
  Myeong-Su Ahn (1)
  Young-Jae Oh (1)
  Minseok Kang (1)
  Yong Jeong (1)
  Ki-Hun Jeong (1)
  
  1. Department of Bio and Brain Engineering and KAIST Institute for Optical Science and Technology ; Korea Advanced Institute of Science and Technology (KAIST) ; 291 Daehak-ro ; Yuseong-gu ; Daejeon ; 305-701 ; Korea
  
• 关键词：Plasmonic nanoparticles ; In vivo SERS ; Neurotransmitter ; Agarose gel ; Beta ; amyloid
• 刊名：BioChip Journal
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：8
• 期：4
• 页码：289-294
• 全文大小：416 KB
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Biotechnology
  
• 出版者：The Korean BioChip Society, in co-publication with Springer Verlag GmbH
• ISSN：2092-7843

文摘

Surfaced enhanced Raman scattering (SERS) has been extensively exploited for label-free and non-destructive biochemical detections. Recently diverse SERS substrates have been reported to improve sensitivity of SERS. However, the current platforms still have technical limitation for in vivo applications. Here, we report a nanoplasmonic biopatch of plasmonic nanoparticles physically embedded in highly biocompatible and Raman inactive agarose hydrogel. Molecular diffusion of small molecules such as neurotransmitter through nanoplasmonic biopatch was quantitatively visualized without labeling by using real-time microscopic SERS. In particular, the nano/micro porous structures within agarose hydrogel allow the SERS detection of macromolecules such as amyloid fibrils. This soft SERS platform opens up new opportunities for in vivo SERS applications.