IL-10 promoter polymorphism associated with decreased risk of aGvHD after stem cell transplantation: a meta-analysis

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• 作者：Ping Zhu (1)
  Li Xie (2)
  Yan Yang (3)
  Jiajun Wang (4)
  Feili Gong (3)
  Min Fang (3)
  
• 关键词：Interleukin ; 10 ; Gene polymorphism ; aGvHD ; Stem cell transplantation
• 刊名：International Journal of Hematology
• 出版年：2013
• 出版时间：July 2013
• 年：2013
• 卷：98
• 期：1
• 页码：102-111
• 全文大小：923KB
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• 作者单位：Ping Zhu (1)
  Li Xie (2)
  Yan Yang (3)
  Jiajun Wang (4)
  Feili Gong (3)
  Min Fang (3)
  
  1. Department of Internal Medicine, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
  2. Department of Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
  3. Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
  4. Department of Immunology, Medical College of China Three Gorges University, Yichang, China
  

文摘

The bulk of evidences indicates that variations in the coding for cytokines or the regulation of their expression may play a role in acute graft-versus-host disease (aGvHD) following allogeneic hematopoietic stem cell transplantation (HSCT). It is unclear whether IL-10 promoter polymorphism is associated with the occurrence of aGvHD in allogeneic HSCT. A systematic search was performed in PubMed and Embase databases and 10 studies were identified for inclusion. Data were extracted and pooled ORs together with 95?% CIs were calculated. The pooled result indicated that ?92A allele in recipient was significantly associated with reduced risk of moderate aGvHD in HSCT [OR?=?0.41 (0.21, 0.79), P?=?0.008, I 2?=?25?%]. The same pattern was also obtained from the ?19T allele in recipient [OR?=?0.38 (0.18, 0.79), P?=?0.01, I 2?=?41?%]. Furthermore, we found a significant positive correlation between the ?92AA homozygote and lower risk of severe aGvHD in HSCT [OR?=?0.54 (0.34, 0.86), P?=?0.01, I 2?=?29?%]. The similar result was gained from the ?082A allele in recipient and decreased risk of severe aGvHD [OR?=?0.71 (0.52, 0.98), P?=?0.04, I 2?=?19?%]. However, there was no significant association between ?92A, ?19T, or ?082A allele in donor and risk of aGvHD. This meta-analysis suggests that the IL-10 A allele or AA homozygote at ?92, T allele at ?19 and the A allele at ?082 are associated with reduced risk of aGvHD in allogeneic HSCT.