Relationship of Serum Mannose-Binding Lectin Levels with the Development of Sepsis: a Meta-analysis

详细信息    查看全文

• 作者：Dong-Na Gao ; Yu Zhang ; Yan-Bo Ren ; Jian Kang ; Li Jiang ; Zhuo Feng…
• 关键词：mannose ; binding lectin ; sepsis ; meta ; analysis
• 刊名：Inflammation
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：38
• 期：1
• 页码：338-347
• 全文大小：380 KB
• 参考文献：1. Shime, N., T. Kawasaki, O. Saito, Y. Akamine, Y. Toda, M. Takeuchi, et al. 2012. Incidence and risk factors for mortality in paediatric severe sepsis: results from the national paediatric intensive care registry in Japan. / Intensive Care Medicine 38: 1191-197. CrossRef
  2. Walkey, A.J., M.A. Greiner, S.R. Heckbert, P.N. Jensen, J.P. Piccini, M.F. Sinner, et al. 2013. Atrial fibrillation among Medicare beneficiaries hospitalized with sepsis: incidence and risk factors. / Am Heart J 165: 949-55 e943. CrossRef
  3. Andaluz-Ojeda, D., V. Iglesias, F. Bobillo, R. Almansa, L. Rico, F. Gandia, et al. 2011. Early natural killer cell counts in blood predict mortality in severe sepsis. / Critical Care 15: R243. CrossRef
  4. Nasa, P., D. Juneja, O. Singh, R. Dang, and V. Arora. 2012. Severe sepsis and its impact on outcome in elderly and very elderly patients admitted in intensive care unit. / Journal of Intensive Care Medicine 27: 179-83. CrossRef
  5. Wang, H.E., N.I. Shapiro, M.M. Safford, R. Griffin, S. Judd, J.B. Rodgers, et al. 2013. High-sensitivity C-reactive protein and risk of sepsis. / PLoS ONE 8: e69232. CrossRef
  6. Westphal, G.A., A. Koenig, M. Caldeira Filho, J. Feijo, L.T. de Oliveira, F. Nunes, et al. 2011. Reduced mortality after the implementation of a protocol for the early detection of severe sepsis. / Journal of Critical Care 26: 76-1. CrossRef
  7. Martin, G.S. 2012. Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes. / Expert Review of Anti-Infective Therapy 10: 701-06. CrossRef
  8. Angus, D.C., and T. van der Poll. 2013. Severe sepsis and septic shock. / The New England Journal of Medicine 369: 840-51. CrossRef
  9. Ward, P.A., and M. Bosmann. 2012. A historical perspective on sepsis. / The American Journal of Pathology 181: 2-. CrossRef
  10. Satar, M., and F. Ozlu. 2012. Neonatal sepsis: a continuing disease burden. / The Turkish Journal of Pediatrics 54: 449-57.
  11. Reinhart, K., M. Bauer, N.C. Riedemann, and C.S. Hartog. 2012. New approaches to sepsis: molecular diagnostics and biomarkers. / Clinical Microbiology Reviews 25: 609-34. CrossRef
  12. Juutilainen, A., S. Hamalainen, K. Pulkki, T. Kuittinen, T. Nousiainen, E. Jantunen, et al. 2011. Biomarkers for bacteremia and severe sepsis in hematological patients with neutropenic fever: multivariate logistic regression analysis and factor analysis. / Leukemia and Lymphoma 52: 2349-355. CrossRef
  13. Hall, T.C., D.K. Bilku, D. Al-Leswas, C. Horst, and A.R. Dennison. 2011. Biomarkers for the differentiation of sepsis and SIRS: the need for the standardisation of diagnostic studies. / Irish Journal of Medical Science 180: 793-98. CrossRef
  14. Ozdemir, O., E.C. Dinleyici, N. Tekin, O. Colak, and M.A. Aksit. 2010. Low-mannose-binding lectin levels in susceptibility to neonatal sepsis in preterm neonates with fetal inflammatory response syndrome. / The Journal of Maternal-Fetal & Neonatal Medicine 23: 1009-013. CrossRef
  15. Frakking, F.N., N. Brouwer, N.K. van Eijkelenburg, M.P. Merkus, T.W. Kuijpers, M. Offringa, et al. 2007. Low mannose-binding lectin (MBL) levels in neonates with pneumonia and sepsis. / Clinical and Experimental Immunology 150: 255-62. CrossRef
  16. de Bene
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Rheumatology
  Internal Medicine
  Pharmacology and Toxicology
  Pathology
  
• 出版者：Springer Netherlands
• ISSN：1573-2576

文摘

Many studies have evaluated the association between serum levels of mannose-binding lectin (MBL) and sepsis; however, the findings are inconclusive and conflicting. For a better understanding of MBL in sepsis, we conducted a comprehensive meta-analysis. Potential relevant studies were identified covering Science Citation Index, the Cochrane Library, PubMed, Embase, CINAHL, and Current Contents Index databases. Two reviewers extracted data and assessed studies independently. Statistical analyses were conducted with the version 12.0 STATA statistical software. Ten papers were collected for meta-analysis. Results identified that sepsis patients had considerably lower MBL level than those in the controls (standardized mean difference (SMD)--.59, 95 % confidence interval (95%CI)--.86?.31, P--.001). Ethnicity-subgroup analysis showed that sepsis patients were associated with decreased serum MBL level in contrast to the healthy controls in Asians (SMD--.07, 95%CI--.27?.88, P--.001) and Caucasians (SMD--.00, 95%CI--.35?.65, P--.003). In the group-stratified subgroup analysis, subjects with lower serum MBL level did underpin susceptibility to sepsis in the infants subgroup (SMD--.57, 95%CI--.59?.55, P--.001); however, this was not the case in the adults subgroup (SMD--.13, 95%CI-??1.30?.55, P--.862). Our study suggests an important involvement of serum MBL level in sepsis patients considering their lower level compared to controls, especially among infants.