MiR-302a/b/c/d cooperatively sensitizes breast cancer cells to adriamycin via suppressing P-glycoprotein(P-gp) by targeting MAP/ERK kinase kinase 1 (MEKK1)

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• 作者：Lin Zhao ; Yan Wang ; Longyang Jiang ; Miao He…
• 关键词：MiR ; 302 ; Breast cancer ; MEKK1 ; Drug resistance
• 刊名：Journal of Experimental & Clinical Cancer Research
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：35
• 期：1
• 全文大小：3,584 KB
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• 作者单位：Lin Zhao (1)
  Yan Wang (1)
  Longyang Jiang (1)
  Miao He (1)
  Xuefeng Bai (1)
  Lifeng Yu (1)
  Minjie Wei (1)
  
  1. Department of Pharmacology, School of Pharmacy, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang City, 110122, Liaoning, China
  
• 刊物主题：Oncology; Cancer Research;
• 出版者：BioMed Central
• ISSN：1756-9966

文摘

Background The importance of individual microRNAs (miRNAs) in tumor has been established in different cancers. However, their association with tumor chemoresistance has not been fully understood. Previously, we found two novel MDR-associated microRNAs (miRNAs). In this report, we investigated the combined effects of miRNA gene cluster in chemoresistance of breast cancer.