Nrf2 Weaves an Elaborate Network of Neuroprotection Against Stroke
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- 作者：Shuai Jiang ; Chao Deng ; Jianjun Lv ; Chongxi Fan ; Wei Hu…
- 关键词：Nuclear factor erythroid 2 ; related factor 2 ; Oxidative stress ; Ischemia ; Hemorrhage
- 刊名：Molecular Neurobiology
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：54
- 期：2
- 页码：1440-1455
- 全文大小：
- 刊物主题：Neurosciences; Neurobiology; Cell Biology; Neurology;
- 出版者：Springer US
- ISSN：1559-1182
- 卷排序：54
文摘
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a neuroprotective transcription factor that has recently attracted increased attention. Stroke, a common and serious neurological disease, is currently a leading cause of death in the USA so far. It is therefore of vital importance to explore how Nrf2 behaves in stroke. In this review, we first introduce the structural features of Nrf2 and Kelch-like ECH-associated protein 1 (Keap1) and briefly depict the activation, inactivation, and regulation processes of the Nrf2 pathway. Next, we discuss the physiopathological mechanisms, upstream modulators, and downstream targets of the Nrf2 pathway. Following this background, we expand our discussion to the roles of Nrf2 in ischemic and hemorrhagic stroke and provide several potential future directions. The information presented here may be useful in the design of future experimental research and increase the likelihood of using Nrf2 as a therapeutic target for stroke in the future.