The role of cancer-associated fibroblasts in esophageal cancer

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• 作者：Jiangfeng Wang ; Guangyu Zhang ; Jianbo Wang ; Lu Wang…
• 关键词：Esophageal cancer ; Cancer ; associated fibroblasts ; Carcinogenesis ; Progression ; Metastasis ; Prognosis ; Treatment
• 刊名：Journal of Translational Medicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：14
• 期：1
• 全文大小：1,292 KB
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• 作者单位：Jiangfeng Wang (1)
  Guangyu Zhang (1)
  Jianbo Wang (1)
  Lu Wang (1)
  Xiaochen Huang (1)
  Yufeng Cheng (1)
  
  1. Department of Radiation Oncology, Qilu Hospital of Shandong University, No 107 West Wenhua Road, Jinan, 250012, People’s Republic of China
  
• 刊物主题：Biomedicine general; Medicine/Public Health, general;
• 出版者：BioMed Central
• ISSN：1479-5876

文摘

Fibroblasts are known as critical stromal cells in wound healing by synthesizing extracellular matrix and collagen. A subpopulation of them is called cancer-associated fibroblasts (CAFs), because their production of proteins participated in various biological activities including tumor cell proliferation, invasion and metastasis. Currently some studies shed light on their role in esophageal cancer which was an aggressive cancer with a dismal survival and high rate of metastasis. Thus, to find cures for it relies on elucidating the epithelial-fibroblasts crosstalk. Herein, we reviewed the present knowledge of the CAFs’ role in esophageal premalignant condition, cancer initiation, progression, metastasis and prognosis prediction and further provided some insights into its clinical application. Keywords Esophageal cancer Cancer-associated fibroblasts Carcinogenesis Progression Metastasis Prognosis Treatment