Preparation and characterization of electrospun polyvinyl alcoholstyrylpyridinium/lus-plus">β-cyclodextrin composite nanofibers: Release behavior and potential use for wound dressing

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• 作者：Jianbo Zhou ; Qingqing Wang ; Hangyi Lu ; Quan Zhang ; Pengfei Lv…
• 关键词：Polyvinyl alcohol ; styrylpyridinium ; β ; cyclodextrin ; Electrospinning ; Mechanical properties ; Drug release
• 刊名：Fibers and Polymers
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：17
• 期：11
• 页码：1835-1841
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Polymer Sciences;
• 出版者：The Korean Fiber Society
• ISSN：1875-0052
• 卷排序：17

文摘

Biocompatible polyvinyl alcohol (PVA)-styrylpyridinium (SbQ)/β-cyclodextrin (β-CD) composite nanofibers were obtained by electrospinning in this study. PVA-SbQ was used as the foundation polymer as well as crosslinking agent, β-CD was incorporated to achieve expected properties such as improved mechanical properties and thermal stability. The Fourier transform infrared spectroscopy (FTIR) spectra confirmed the existence of β-CD, and the morphologies and average fiber diameters of the electrospun composite nanofibers were also analyzed by SEM. X-ray diffraction patterns (XRD) of PVA-SbQ/β-CD composite nanofibers revealed that the inclusion of β-CD in the nanofibers affected the ordered phase of PVA. Besides, the thermal analyses revealed the improvement in the thermal properties for PVA-SbQ/β-CD composite nanofibers. It was found that the crosslinked composite nanofibers showed a clear higher tensile strength (TS) as well as a greater elongation at break (EB). Eventually, antifungal drug griseofulvin (GSV) has been loaded into the composite nanofibers by formation of its inclusion complex with β-CD in aqueous solution, ultraviolet light (UV-Vis) spectral analysis showed that the drug-loading nanofibers had certain sustained release effect.