Immune safety of a novel oncolytic mutant M1 after administration In Vivo
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  • 作者:Lijun Jiang (1)
    Xiaoxi Zhou (1)
    Qinlu Li (1)
    Fei Yu (2)
    Liang Huang (1)
    Quanfu Ma (2)
    Jianfeng Zhou (1)
    Yang Cao (1)
  • 关键词:adenovirus M1 ; immunity ; safety
  • 刊名:Journal of Huazhong University of Science and Technology [Medical Sciences]
  • 出版年:2012
  • 出版时间:August 2012
  • 年:2012
  • 卷:32
  • 期:4
  • 页码:517-523
  • 全文大小:1186KB
  • 参考文献:1. Mizuguchi H, Hayakawa T. Targeted adenovirus vectors. HumGene Ther, 2004,15(11):1034-044
    2. Wei Q, Liu Z, Fei Y, / et al. Adeno-associated viral vector mediated and cardiac-specific delivery of CD151 gene in ischemic rat hearts. J Huazhong Univ Sci Technol Med Sci, 2011,31(1):46-1 CrossRef
    3. Zhou J, Gao Q, Chen G, / et al. Novel oncolytic adenovirus selectively targets tumor-associated polo-like kinase 1 and tumor cell viability. Clin Cancer Res, 2005,11(23): 8431-440 CrossRef
    4. Morral N, O’Neal WK, Rice K, / et al. Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons. Hum Gene Ther, 2002,13(1):143-54 CrossRef
    5. Sullivan DE, Dash S, Du H, / et al. Liver-directed gene transfer in non-human primates. Hum Gene Ther, 1997,8(10):1195-206 CrossRef
    6. Zamir G, Gelman AE, Olthoff KM, / et al. Patterns of transgene expression and viral clearance from the transplanted liver following / ex vivo adenovirus-mediated gene transfer. J Hepatol, 2004,41(5):714-20 CrossRef
    7. Bessis N, Garciacozar FJ, Boisser MC. Immune responses to gene therapy vectors: influence on vector function and effector mechanisms. Gene Ther, 2004,11(1): 10-7 CrossRef
    8. Bouvet M, Fang B, Ekmekcioglu S, / et al. Suppression of immune response to an adenovirus vector and enhancement of intratumoral transgene expression by low-dose etoposide. Gene Ther, 1985,5(2):189-95 CrossRef
    9. Kawahara T, Murakami S, Noiri Y, / et al. Effects of cyclosporine-A-induced immunosuppression on periapical lesions in rats. J Dent Res, 2004,83(9):683-87 CrossRef
  • 作者单位:Lijun Jiang (1)
    Xiaoxi Zhou (1)
    Qinlu Li (1)
    Fei Yu (2)
    Liang Huang (1)
    Quanfu Ma (2)
    Jianfeng Zhou (1)
    Yang Cao (1)

    1. Department of Hematology, Huazhong University of Science and Technology, Wuhan, 430030, China
    2. Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
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