The sequence and analysis of a Chinese pig genome

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• 作者：Xiaodong Fang (1)
  Yulian Mou (2)
  Zhiyong Huang (1)
  Yong Li (1) (3) (4)
  Lijuan Han (1)
  Yanfeng Zhang (5)
  Yue Feng (1)
  Yuanxin Chen (1)
  Xuanting Jiang (1)
  Wei Zhao (1)
  Xiaoqing Sun (1)
  Zhiqiang Xiong (1)
  Lan Yang (1)
  Huan Liu (1) (3) (4)
  Dingding Fan (1)
  Likai Mao (1)
  Lijie Ren (6)
  Chuxin Liu (1) (3) (4)
  Juan Wang (1)
  Kui Li (2)
  Guangbiao Wang (1)
  Shulin Yang (2)
  Liangxue Lai (7)
  Guojie Zhang (1)
  Yingrui Li (1)
  Jun Wang (1) (8) (9)
  Lars Bolund (1) (10)
  Huanming Yang (1)
  Jian Wang (1)
  Shutang Feng (2)
  Songgang Li (1)
  Yutao Du (1) (3) (4)
  
• 关键词：Wuzhishan pig ; Genome ; Homozygosis ; Transposable element ; Endogenous retrovirus ; Animal model
• 刊名：GigaScience
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：1
• 期：1
• 全文大小：377KB
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• 作者单位：Xiaodong Fang (1)
  Yulian Mou (2)
  Zhiyong Huang (1)
  Yong Li (1) (3) (4)
  Lijuan Han (1)
  Yanfeng Zhang (5)
  Yue Feng (1)
  Yuanxin Chen (1)
  Xuanting Jiang (1)
  Wei Zhao (1)
  Xiaoqing Sun (1)
  Zhiqiang Xiong (1)
  Lan Yang (1)
  Huan Liu (1) (3) (4)
  Dingding Fan (1)
  Likai Mao (1)
  Lijie Ren (6)
  Chuxin Liu (1) (3) (4)
  Juan Wang (1)
  Kui Li (2)
  Guangbiao Wang (1)
  Shulin Yang (2)
  Liangxue Lai (7)
  Guojie Zhang (1)
  Yingrui Li (1)
  Jun Wang (1) (8) (9)
  Lars Bolund (1) (10)
  Huanming Yang (1)
  Jian Wang (1)
  Shutang Feng (2)
  Songgang Li (1)
  Yutao Du (1) (3) (4)
  
  1. BGI-Shenzhen, Bei Shan Road, Yantian, Shenzhen, 518083, China
  2. Institute of Animal Science (IAS), Chinese Academy of Agriculture Science (CAAS), Beijing, 10094, China
  3. Shenzhen Engineering Laboratory for Genomics-Assisted Animal Breeding, BGI-Shenzhen, Bei Shan Road, Yantian, Shenzhen, 518083, China
  4. BGI Ark Biotechnology (BAB), Bei Shan Road, Yantian, Shenzhen, 518083, China
  5. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
  6. Department of Neurology, Shenzhen Second People鈥檚 Hospital (First Affiliated Hospital of Shenzhen University), Shenzhen, 518035, China
  7. Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangdong, China
  8. Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
  9. Department of Biology, University of Copenhagen, Copenhagen, Denmark
  10. Department of Biomedicine, Aarhus University, Aarhus C, Denmark
  
• ISSN：2047-217X

文摘

Background The pig is an economically important food source, amounting to approximately 40% of all meat consumed worldwide. Pigs also serve as an important model organism because of their similarity to humans at the anatomical, physiological and genetic level, making them very useful for studying a variety of human diseases. A pig strain of particular interest is the miniature pig, specifically the Wuzhishan pig (WZSP), as it has been extensively inbred. Its high level of homozygosity offers increased ease for selective breeding for specific traits and a more straightforward understanding of the genetic changes that underlie its biological characteristics. WZSP also serves as a promising means for applications in surgery, tissue engineering, and xenotransplantation. Here, we report the sequencing and analysis of an inbreeding WZSP genome. Results Our results reveal some unique genomic features, including a relatively high level of homozygosity in the diploid genome, an unusual distribution of heterozygosity, an over-representation of tRNA-derived transposable elements, a small amount of porcine endogenous retrovirus, and a lack of type C retroviruses. In addition, we carried out systematic research on gene evolution, together with a detailed investigation of the counterparts of human drug target genes. Conclusion Our results provide the opportunity to more clearly define the genomic character of pig, which could enhance our ability to create more useful pig models.