Calcium Signaling Involvement in Cadmium-Induced Astrocyte Cytotoxicity and Cell Death Through Activation of MAPK and PI3K/Akt Signaling Pathways
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- 作者：Jiao Hua Jiang ; Guo Ge ; Kai Gao ; Ying Pang ; Rui Chao Chai…
- 关键词：Astrocytes ; Cadmium ; Cytotoxicity ; MAPK ; PI3K/Akt
- 刊名：Neurochemical Research
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：40
- 期：9
- 页码：1929-1944
- 全文大小：13,229 KB
- 参考文献：1.Choong G, Liu Y, Templeton DM (2014) Interplay of calcium and cadmium in mediating cadmium toxicity. Chem Biol Interact 211:54-5CrossRef PubMed
2.Mendez-Armenta M, Rios C (2007) Cadmium neurotoxicity. Environ Toxicol Pharmacol 23:350-58CrossRef PubMed
3.Wang B, Du Y (2013) Cadmium and its neurotoxic effects. Oxid Med Cell Longev 2013:898034PubMed Central PubMed
4.Okuda B, Iwamoto Y, Tachibana H, Sugita M (1997) Parkinsonism after acute cadmium poisoning. Clin Neurol Neurosurg 99:263-65CrossRef PubMed
5.Du Y, Shang Q (2006) Review of effect on human health for environmental cadmium pollution. Wei Sheng Yan Jiu 35:241-43PubMed
6.Waisberg M, Joseph P, Hale B, Beyersmann D (2003) Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 192:95-17CrossRef PubMed
7.Chang YF, Wen JF, Cai JF, Xiao-Ying W, Yang L, Guo YD (2012) An investigation and pathological analysis of two fatal cases of cadmium poisoning. Forensic Sci Int 220:e5-CrossRef PubMed
8.Evans J, Hastings L (1992) Accumulation of Cd(II) in the CNS depending on the route of administration: intraperitoneal, intratracheal, or intranasal. Fundam Appl Toxicol 19:275-78CrossRef PubMed
9.Abbott NJ, Ronnback L, Hansson E (2006) Astrocyte-endothelial interactions at the blood–brain barrier. Nat Rev Neurosci 7:41-3CrossRef PubMed
10.Tiffany-Castiglioni E, Sierra EM, Wu JN, Rowles TK (1989) Lead toxicity in neuroglia. Neurotoxicology 10:417-43PubMed
11.Li C, Zhao R, Gao K, Wei Z, Yin MY, Lau LT, Chui D, Hoi Yu AC (2011) Astrocytes: implications for neuroinflammatory pathogenesis of Alzheimer’s disease. Curr Alzheimer Res 8:67-0CrossRef PubMed
12.Ransom B, Behar T, Nedergaard M (2003) New roles for astrocytes (stars at last). Trends Neurosci 26:520-22CrossRef PubMed
13.Liang HJ, Chai RC, Li X, Kong JG, Jiang JH, Ma J, Vatcher G, Yu AC (2015) Astrocytic exportin-7 responds to ischemia through mediating LKB1 translocation from the nucleus to the cytoplasm. J Neurosci Res 93:253-67CrossRef PubMed
14.Chai RC, Jiang JH, Kwan Wong AY, Jiang F, Gao K, Vatcher G, Hoi Yu AC (2013) AQP5 is differentially regulated in astrocytes during metabolic and traumatic injuries. Glia 61:1748-765CrossRef PubMed
15.Dong Y, Liu HD, Zhao R, Yang CZ, Chen XQ, Wang XH, Lau LT, Chen J, Yu AC (2009) Ischemia activates JNK/c-Jun/AP-1 pathway to up-regulate 14-3-3gamma in astrocyte. J Neurochem 109(Suppl 1):182-88CrossRef PubMed
16.Gao K, Wang CR, Jiang F, Wong AY, Su N, Jiang JH, Chai RC, Vatcher G, Teng J, Chen J, Jiang YW, Yu AC (2013) Traumatic scratch injury in astrocytes triggers calcium influx to activate the JNK/c-Jun/AP-1 pathway and switch on GFAP expression. Glia 61:2063-077CrossRef PubMed
17.Pang Y, Chai CR, Gao K, Jia XH, Kong JG, Chen XQ, Vatcher G, Chen JG, Yu AC (2015) Ischemia preconditioning protects astrocytes from ischemic injury through 14-3-3gamma. J Neurosci Res. doi:10.-002/?jnr.-3574 PubMed
18.Chen L, Liu L, Luo Y, Huang S (2008) MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem 105:251-61CrossRef PubMed
19.Jung YS, Jeong EM, Park EK, Kim YM, Sohn S, Lee SH, Baik EJ, Moon CH (2008) Cadmium induces apoptotic cell death through p38 MAPK in brain microvessel endothelial cells. Eur J Pharmacol 578:11-8CrossRef PubMed
20.Xu B, Chen S, Luo Y, Chen Z, Liu L, Zhou H, Chen W, Shen T, Han X, Chen L, Huang S (2011) Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK/mTOR network. PLoS ONE 6:e19052PubMed Central CrossRef PubMed
21.Labudda M (2011) Biochemical mechanisms of neurotoxicity caused by cadmium. Rocz Panstw Zakl Hig 62:357-63PubMed
22.Rigon AP, Cordova FM, Oliveira CS, Posser T, Costa AP, Silva IG, Santos DA, Rossi FM, Rocha JB, Leal RB (2008) Neurotoxicity of cadmium on immature hippocampus and a neuroprotective role for p38 MAPK. Neurotoxicology 29:727-34CrossRef PubMed
23.Lopez E, Figueroa S, Oset-Gasque MJ, Gonzalez MP (2003) Apoptosis and necrosis: two distinct events induced by cadmium in cortical neurons in culture. Br J Pharmacol 138:901-11PubMed Central CrossRef PubMed
24.Yuan Y, Jiang CY, Xu H, Sun Y, Hu FF, Bian JC, Liu XZ, Gu JH, Liu ZP (2013) Cadmium-induced apoptosis in primary rat cerebral cortical neurons culture is mediated by a calcium signaling pathway. PLoS ONE 8:e64330PubMed Central CrossRef PubMed
25.Ransom BR, Ransom CB (2012) Astrocytes: multitalented stars of the central nervous system. Methods Mol Biol 814:3-CrossRef PubMed
26.Yang CS, Tzou BC, Liu YP, Tsai MJ, Shyue SK, Tzeng SF (2008) Inhibition of cadmium-induced oxidative injury in rat primary astrocytes by the addition of antioxidants and the reduction of intracellular calcium. J Cell Biochem 103:825-34CrossRef PubMed
27.Rai A, Maurya SK, Khare P, Srivastava A, Bandyopadhyay S (2010) Characterization of developmental neurotoxicity of A - 作者单位：Jiao Hua Jiang (1) (2)
Guo Ge (1) (2) (4)
Kai Gao (1) (2)
Ying Pang (1) (2)
Rui Chao Chai (1) (2) (5)
Xi Hua Jia (1) (2)
Jin Ge Kong (1) (2)
Albert Cheung-Hoi Yu (1) (2) (3) (5)
1. Neuroscience Research Institute, Key Laboratory for Neuroscience (Ministry of Education) and Key Laboratory for Neuroscience (National Health and Family Planning Commission), Peking University, 38 Xue Yuan Road, Beijing, 100191, China
2. Department of Neurobiology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing, 100191, China
4. Department of Human Anatomy, Guizhou Medical University, Guian New Area, Guiyang, 550025, Guizhou, China
5. Hai Kang Life (Beijing) Corporation Ltd., Sino-I Campus No. 1, Beijing Economic-Technological Development Area, Beijing, 100176, China
3. Laboratory of Translational Medicine, Institute of Systems Biomedicine, Peking University, Beijing, 100191, China - 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Neurosciences
Biochemistry
Neurology - 出版者：Springer Netherlands
- ISSN：1573-6903
文摘
Cadmium (Cd), a highly ubiquitous toxic heavy metal, can contaminate the environment, including agricultural soil, water and air, via industrial runoff and other sources of pollution. Cd accumulated in the body via direct exposure or through the food chain results in neurodegeneration and many other diseases. Previous studies on its toxicity in the central nervous system (CNS) focused mainly on neurons. To obtain a more comprehensive understanding of Cd toxicity for the CNS, we investigated how astrocytes respond to acute and chronic Cd exposure and its toxic molecular mechanisms. When primary cultures of cerebral cortical astrocytes incubated with 1-00 μM CdCl2, morphological changes, LDH release and cell death were observed in a time and dose-dependent manner. Further studies demonstrated that acute and chronic Cd treatment phosphorylated JNK, p38 and Akt to different degrees, while ERK1/2 was only phosphorylated under low doses of Cd (10 μM) exposure. Inhibition of JNK and PI3K/Akt, but not of p38, could partially protect astrocyte from cytotoxicity in chronic and acute Cd exposure. Moreover, Cd also induced a strong calcium signal, while BAPTA, a specific intracellular calcium (Ca2+) chelator, prevented Cd-induced intracellular increase of calcium levels in astrocytes; inhibited the Cd-induced activation of ERK1/2, JNK, p38 and Akt; and also significantly reduced astrocyte cell death. All of these results suggested that the Cd–Ca2+–MAPK and PI3K/Akt signaling pathways were involved in Cd-induced toxicity in astrocytes. This toxicity involvement indicates that these pathways may be exploited as a target for the prevention of Cd-induced neurodegenerative diseases. Keywords Astrocytes Cadmium Cytotoxicity MAPK PI3K/Akt