miR-21 is involved in skeletal deficiencies of zebrafish embryos exposed to polychlorinated biphenyls

详细信息    查看全文

• 作者：Li Ju ; Zhiwen Zhou ; Bo Jiang ; Yue Lou…
• 关键词：Biphenyls ; miR ; 21 ; Skeletal deficiency ; BMPRII ; Calcium ; Zebrafish ; Embryonic development
• 刊名：Environmental Science and Pollution Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：24
• 期：1
• 页码：886-891
• 全文大小：
• 刊物类别：Earth and Environmental Science
• 刊物主题：Environment, general; Environmental Chemistry; Ecotoxicology; Environmental Health; Atmospheric Protection/Air Quality Control/Air Pollution; Waste Water Technology / Water Pollution Control / Water M
• 出版者：Springer Berlin Heidelberg
• ISSN：1614-7499
• 卷排序：24

文摘

Polychlorinated biphenyl (PCB) exposure increases the incidence and severity of skeletal diseases, but little is known about the mechanisms that mediate this relationship. We exposed zebrafish embryos to PCB₁₂₅₄ and assessed the changes in bone morphology protein receptor II (BMPRII), which is involved in bone formation and embryonic development, miRNA-21, for which BMPRII is a known target, and calcium metabolism. PCB₁₂₅₄ upregulated the expression of miR-21 and suppressed BMPRII expression. The inhibition of miR-21 reversed the downregulation of BMPRII and alleviated the PCB₁₂₅₄-induced loss of calcium. These findings suggest new biomarkers of developmental defects of the skeleton caused by PCBs.