Intravoxel incoherent motion diffusion-weighted MR imaging in differentiation of lung cancer from obstructive lung consolidation: comparison and correlation with pharmacokinetic analysis from dynamic contrast-enhanced MR imaging

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• 作者：Li-li Wang (1) (2)
  Jiang Lin (1)
  Kai Liu (1)
  Cai-zhong Chen (1)
  Hui Liu (3)
  Peng Lv (1)
  Cai-xia Fu (3)
  Meng-su Zeng (1)
  
• 关键词：MR ; Diffusion ; Perfusion ; Intravoxel incoherent motion ; Lung cancer
• 刊名：European Radiology
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：24
• 期：8
• 页码：1914-1922
• 全文大小：2,381 KB
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• 作者单位：Li-li Wang (1) (2)
  Jiang Lin (1)
  Kai Liu (1)
  Cai-zhong Chen (1)
  Hui Liu (3)
  Peng Lv (1)
  Cai-xia Fu (3)
  Meng-su Zeng (1)
  
  1. Department of Diagnostic Radiology, Shanghai Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, 200032, China
  2. Xiehe Hospital, Fujian Medical University, Fujian, 350001, China
  3. MR Collaboration NEA, Siemens Ltd. China, Shanghai, China
  
• ISSN：1432-1084

文摘

Objectives To test whether parameters derived from intravoxel incoherent motion (IVIM) can be used to distinguish lung cancer from obstructive pulmonary consolidation by comparing them with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)-derived parameters and to evaluate the correlation between these quantitative parameters. Methods A total of 31 lung cancer patients, confirmed by pathology and obstructive consolidations confirmed by positron emission tomography/computed tomography (PET-CT), were recruited. All of them were assessed with structural MRI and IVIM and 17 of them underwent additional DCE-MRI examinations. Parameters derived from IVIM and DCE-MRI in the tumour and consolidation were analysed, and the optimal cut-off values in differential diagnosis were obtained. Results ADCtotal, D and f values were lower (P--.05), while IAUC60 was higher in lung cancers (P--.013) compared with obstructive pulmonary consolidations. According to the ROC curve, ADCtotal outperformed other perfusion and diffusion parameters with the optimal cut-off value of 1.409?×-0-3?mm2/s (AUC--.95). Poor correlations were found between parameters derived from IVIM and DCE-MRI. Conclusions IVIM-MRI is potentially useful in the differentiation of lung cancer and obstructive pulmonary consolidation. ADCtotal, D and f may be reliable independent discriminating markers, but D * is variable with low diagnostic accuracy. Key Points -Lung cancer and consolidation differentiation is essential for treatment decision-making. -Perfusion and diffusion characteristics of lesions could help differential diagnosis. -IVIM can separate reflection of tissue diffusivity and microcapillary perfusion. -The relationship between perfusion quantified by IVIM and DCE-MRI is controversial.