DNA repair gene XRCC3 Thr241Met polymorphism and hepatocellular carcinoma risk

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• 作者：Chenyang Duan (1)
  Wanli Zhang (2)
  Jiangfeng Lu (3)
  Huawen Wu (4)
  Mengying Liu (5)
  Wentao Zhu (6)
  
• 关键词：Hepatocellular carcinoma ; X ; ray repair cross ; complementing group 3 ; Polymorphism ; Meta ; analysis
• 刊名：Tumor Biology
• 出版年：2013
• 出版时间：October 2013
• 年：2013
• 卷：34
• 期：5
• 页码：2827-2834
• 全文大小：
• 作者单位：Chenyang Duan (1)
  Wanli Zhang (2)
  Jiangfeng Lu (3)
  Huawen Wu (4)
  Mengying Liu (5)
  Wentao Zhu (6)
  
  1. Company Five of Cadet Brigade, Clinical Department of Medicine, Third Military Medical University, Chongqing, 400038, China
  2. Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
  3. Binzhou Medical University, Binzhou, 264003, China
  4. Institute of Electronic Computing Technology, China Academy of Railway Science, Beijing, 100020, China
  5. Company Two of Cadet Brigade, Clinical Department of Medicine, Third Military Medical University, Chongqing, 400038, China
  6. Department of Orthopaedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
  
• ISSN：1423-0380

文摘

The DNA repair genes have been indicated as candidates in the risk of hepatocellular carcinoma (HCC). Published data on the association between X-ray repair cross-complementing group 3 (XRCC3), a critical member of the DNA repair genes, and HCC risk were contradictory. The aim of this meta-analysis was to assess the effect of XRCC3 Thr241Met polymorphism on HCC risk by pooling available data from published caseontrol studies. We calculated the pooled odds ratio (OR) with the corresponding 95% confidence interval (95% CI) to estimate the effect. Based on the inclusion criteria, six individual studies with 2,288 cases and 3,170 controls were included into our study. Overall, significant association between the XRCC3 Thr241Met variant and HCC risk was observed under the following contrast models (ORMet vs. Thr=1.68, 95%CI 1.08.62; ORMetMet vs. ThrThr=5.54, 95%CI 3.09.94; ORMetMet vs. ThrThr+ThrMet=5.70, 95% CI 4.24.64). Besides, the pooled ORs indicated that the XRCC3 Thr241Met polymorphism exerted risk effect on the HCC pathogenesis among Asians. Additionally, when stratifying by the status of smoking and hepatitis B virus infection, the XRCC3 Thr241Met variant was significantly associated with HCC risk among the HBsAg (+) individuals but not the HBsAg () individuals, smokers, and non-smokers. The present meta-analysis suggests that the XRCC3 Thr241Met polymorphism is an independent risk factor for HCC, particularly among Asians and the HBsAg (+) individuals.