Targeted anti-cancer prodrug based on carbon nanotube with photodynamic therapeutic effect and pH-triggered drug release
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- 作者：Jianquan Fan (1)
Fang Zeng (1)
Jiangsheng Xu (1)
Shuizhu Wu (1) - 关键词：Targeted ; Prodrug ; Photodynamic ; pH ; triggered release ; Carbon nanotube
- 刊名：Journal of Nanoparticle Research
- 出版年：2013
- 出版时间：September 2013
- 年：2013
- 卷：15
- 期：9
- 全文大小：741KB
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Fang Zeng (1)
Jiangsheng Xu (1)
Shuizhu Wu (1)
1. College of Materials Science & Engineering, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510640, China
文摘
Herein, we describe a multifunctional anti-cancer prodrug system based on water-dispersible carbon nanotube (CNT); this prodrug system features active targeting, pH-triggered drug release, and photodynamic therapeutic properties. For this prodrug system (with the size of ~100-00?nm), an anti-cancer drug, doxorubicin (DOX), was incorporated onto CNT via a cleavable hydrazone bond; and a targeting ligand (folic acid) was also coupled onto CNT. This prodrug can preferably enter folate receptor (FR)-positive cancer cells and undergo intracellular release of the drug triggered by the reduced pH. The targeted CNT-based prodrug system can cause lower cell viability toward FR-positive cells compared to the non-targeted ones. Moreover, the CNT carrier exhibits photodynamic therapeutic (PDT) action; and the cell viability of FR-positive cancer cells can be further reduced upon light irradiation. The dual effects of pH-triggered drug release and PDT increase the therapeutic efficacy of the DOX–CNT prodrug. This study may offer some useful insights on designing and improving the applicability of CNT for other drug delivery systems.