Effect of exogenous nitric oxide on sperm motility in vitro

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• 作者：Jiangtao Wang ; Qingliu He ; Xingyu Yan ; Youmei Cai ; Junyi Chen
• 关键词：Nitric oxide ; Sperm capacitation ; Sperm motility ; Time ; Human
• 刊名：Biological Research
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：47
• 期：1
• 全文大小：822KB
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• 作者单位：Jiangtao Wang (1)
  Qingliu He (2)
  Xingyu Yan (2)
  Youmei Cai (3)
  Junyi Chen (2)
  
  1. Departments of Urology, Affiliated Hospital, Shandong Medical college, Linyi, Shandong, China
  2. Departments of Urology, Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
  3. Departments of Ophthalmology, Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
  
• 刊物类别：Life Sciences, general; Cell Biology; Neurosciences; Developmental Biology; Microbiology; Plant Scie
• 刊物主题：Life Sciences, general; Cell Biology; Neurosciences; Developmental Biology; Microbiology; Plant Sciences;
• 出版者：BioMed Central
• ISSN：0717-6287

文摘

Background Nitric oxide (NO) has been shown to be important in sperm function, and the concentration of NO appears to determine these effects. Studies have demonstrated both positive and negative effects of NO on sperm function, but have not been able to provide a clear link between NO concentration and the extent of exposure to NO. To study the relationship between nitric oxide and sperm capacitation in vitro, and to provide a theoretical basis for the use of NO-related preparations in improving sperm motility for in vitro fertilization, we investigated the effects of NO concentration and time duration at these concentrations on in vitro sperm capacitation in both normal and abnormal sperm groups. We manipulated NO concentrations and the time duration of these concentrations using sodium nitroprusside (an NO donor) and NG-monomethyl-L-argenine (an NO synthase inhibitor).