Increased expression of T cell immune response cDNA 7 in patients with acute graft-versus-host disease

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• 作者：Feng Zhu ; Jianlin Qiao ; Wei Chen ; Bin Pan ; Qing-yun Wu ; Jiang Cao…
• 关键词：T cell immune response cDNA 7 ; Allogeneic hematopoietic stem cell transplantation ; Acute graft ; versus ; host disease ; T helper cell
• 刊名：Annals of Hematology
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：94
• 期：6
• 页码：1025-1032
• 全文大小：293 KB
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• 作者单位：Feng Zhu (1)
  Jianlin Qiao (1) (2)
  Wei Chen (1) (2)
  Bin Pan (1) (2)
  Qing-yun Wu (1) (2)
  Jiang Cao (1)
  Wei Sang (1)
  Zhi-ling Yan (1)
  Ling-yu Zeng (1) (2)
  Zhen-yu Li (1)
  Kai-lin Xu (1) (2)
  
  1. Department of Hematology, The Affiliated Hospital of Xuzhou Medical College, 99 West Huaihai Road, Xu Zhou, 221002, Jiangsu, China
  2. Laboratory of Transplant Immunology, Xuzhou Medical College, 84 West Huaihai Road, Xu Zhou, 221002, Jiangsu, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Hematology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0584

文摘

Acute graft-versus-host disease (aGVHD) has become the important complication post-allogeneic hematopoietic stem cell transplantation. Abnormally activated T cells might play an important role in the pathogenesis of aGVHD. But its exact mechanism remains poorly understood. T cell immune response cDNA 7 (TIRC7) has been identified to be essential in T cell activation; however, the role of TIRC7 in aGVHD remains unclear. The purpose of this study was to measure the expression of TIRC7 and T helper (Th) cells in patients with aGVHD before and after treatment. We showed that TIRC7 levels in aGVHD patients were higher than those of healthy controls and markedly declined after treatment. The levels of IFN-γ (Th1), IL-17 (Th17), and IL-22 (Th22) were in accordance with the grade of aGVHD. In addition, TIRC7 levels were also associated with the severity of aGVHD. In conclusion, TIRC7 might be involved in the pathogenesis of aGVHD and TIRC7 level might be an indicator to evaluate the response of patients with aGVHD to treatment.