Lack of association between microRNA-137 SNP rs1625579 and schizophrenia in a replication study of Han Chinese

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• 作者：Jianmin Yuan ; Zaohuo Cheng ; Fuquan Zhang ; Zhenhe Zhou…
• 关键词：Schizophrenia ; MicroRNA ; 137 ; Single ; nucleotide polymorphism ; Allele ; Han Chinese
• 刊名：Molecular Genetics and Genomics
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：290
• 期：1
• 页码：297-301
• 全文大小：268 KB
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• 作者单位：Jianmin Yuan (1)
  Zaohuo Cheng (1)
  Fuquan Zhang (1)
  Zhenhe Zhou (1)
  Shui Yu (1)
  Chunhui Jin (1)
  
  1. Wuxi Mental Health Center Affiliated to Nanjing Medical University, Wuxi, 214151, Jiangsu Province, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Biochemistry
  Microbial Genetics and Genomics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1617-4623

文摘

Schizophrenia (SCZ) is a common, complex and severe psychiatric disorder associated with many different genetic and environmental risk factors. A recent genome-wide association study identified a single-nucleotide polymorphism (SNP, rs1625579) in microRNA-137 (miR-137) as a possible susceptibility locus for SCZ. Hoping to validate this finding, we conducted a case–control study of the Han Chinese population, with 506 SCZ cases and 522 healthy controls, using the Ligase detection reaction–polymerase chain reaction method to genotype the polymorphism rs1625579 in the miR-137 gene. However, we found no significant difference (P?>?0.05) in either allele or genotype frequency in this SNP between patients and controls. In addition, a meta-analysis indicated that the ‘T-allele of SNP rs1625579 was not associated with susceptibility to SCZ in Han Chinese populations (pooled OR 1.087, 95?% CI 0.847-.396, P?=?0.512). Thus, these results do not support the previous finding suggesting further replication studies using a large-scale association analysis that should be warranted in Han Chinese populations.