Synthesis and biodistribution of novel dipicolylamine ^99mTc-(CO)₃-labeled fatty acid derivatives for myocardial imaging

详细信息    查看全文

• 作者：Qianqian Xue ; Huan Wang ; Jianping Liu…
• 关键词：99mTc ; (CO)3 ; labeled ; Fatty acid ; Dipicolylamine ; Myocardial imaging ; Biodistribution
• 刊名：Journal of Radioanalytical and Nuclear Chemistry
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：310
• 期：3
• 页码：1181-1194
• 全文大小：991 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nuclear Chemistry
  Physical Chemistry
  Nuclear Physics, Heavy Ions and Hadrons
  Diagnostic Radiology
  Inorganic Chemistry
  
• 出版者：Akad茅miai Kiad贸, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic
• ISSN：1588-2780
• 卷排序：310

文摘

Six novel long chain fatty derivatives with dipicolylamine ligand were designed and synthesized and incorporated with fac-[99mTc(CO)₃]+ as potential myocardial metabolic SPECT agents. They were prepared in a radiolabeling yield and demonstrated positively charged. The chemical stability of these compounds were good. Biodistribution studies were performed in normal mice, all compounds showed good initial heart uptake and retention, for 1b the heart uptake was 3.28 %ID/g at 1 min and could keep with 1.11 %ID/g at 60 min, it also showed a rapid blood clearance (blood_1 min/blood_60 min = 28).