Calreticulin down-regulation inhibits the cell growth, invasion and cell cycle progression of human hepatocellular carcinoma cells
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- 作者：Ruo Feng ; Jianwen Ye ; Chuang Zhou ; Lei Qi ; Zhe Fu ; Bing Yan…
- 刊名：Diagnostic Pathology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：10
- 期：1
- 全文大小：3,044 KB
- 刊物主题：Pathology;
- 出版者：BioMed Central
- ISSN：1746-1596
文摘
Background Hepatocellular carcinoma (HCC) is one of the most frequent cancers in the world. Calreticulin(CRT) is aberrantly overexpressed in many human cancer cells. The function of CRT in HCC cells remains unclear. We attempted to investigate the effects and the underlying mechanisms of CRT down-regulation on HCC cell growth, apoptosis, cell cycle progression and invasion.