Decreased expression of microRNA-107 predicts poorer prognosis in glioma

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• 作者：Yuchen Ji ; Yujun Wei ; Jianyong Wang ; Qiang Ao ; Kai Gong ; Huancong Zuo
• 关键词：Glioma ; microRNA ; 107 ; Overall survival ; Progression ; free survival
• 刊名：Tumor Biology
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：36
• 期：6
• 页码：4461-4466
• 全文大小：360 KB
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• 作者单位：Yuchen Ji (1) (2)
  Yujun Wei (1) (2)
  Jianyong Wang (3)
  Qiang Ao (1) (2)
  Kai Gong (1) (2)
  Huancong Zuo (1) (2)
  
  1. Medical Center, Tsinghua University, Haidian District, Beijing, 100084, China
  2. Department of Neurosurgery, Yuquan Hospital ,Tsinghua University, Shijingshan district, Beijing, 100040, China
  3. School of clinical Medicine, Inner Mongolia University for the Nationalities, Tongliao, 028000, China
  
• 刊物主题：Cancer Research;
• 出版者：Springer Netherlands
• ISSN：1423-0380

文摘

The expression level of microRNA-107 (miR-107) has been proved to be decreased in many human malignant cancers. Especially in glioma, accumulating evidence indicates that miR-107 may play important parts in cell proliferation, apoptosis, and invasion in glioma. However, its clinical significance in glioma has not been investigated. This study aims at investigating the relationship between miR-107 expression level and clinical significance and analyzing its value of miR-107 in valuing the prognosis of glioma patients. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to measure the expression of miR-107 in 80 glioma and 17 normal brain tissues. The results showed the miR-107 expression level in glioma tissues was significantly lower than those in normal brain tissues (p-lt;-.001). The decreased expression of miR-107 in glioma was positively associated with high WHO grade (p-lt;-.001), low Karnofsky performance score (KPS) (p-lt;-.001), and large tumor size (p-lt;-.001) and had a significant impact on overall survival (OS) (p-lt;-.001) and progression-free survival (PFS) (p-lt;-.001) according to Kaplan–Meier survival with log-rank test. Finally, Cox regression analyses showed that low miR-107 expression (p-lt;-.001) might be an independent prognostic parameter to predict poor prognosis. In conclusion, it is the first data to prove that expression level of miR-107 may be a novel and valuable prognostic factor in glioma.